Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential

In order to evaluate the significance of matrix metalloproteinases (MMPs) in predicting the metastatic potential of oral squamous cell carcinomas (SCCs), we compared MMP-2 and -9 expression in 19 metastasizing oral SCCs with that in 25 non-metastasizing cases by immunohistochemistry and gelatin zymo...

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Bibliographic Details
Published in:Oral oncology 2000-03, Vol.36 (2), p.207-213
Main Authors: Hong, Seong-Doo, Hong, Sam-Pyo, Lee, Jae-Il, Lim, Chang-Yun
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - secondary
Gelatin zymography
Humans
Immunohistochemistry
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - metabolism
Medical sciences
Metastasis
MMP-2
MMP-9
Mouth Neoplasms - enzymology
Mouth Neoplasms - pathology
Neoplasm Metastasis
Neoplasm Proteins - metabolism
Otorhinolaryngology. Stomatology
Squamous cell carcinoma
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:In order to evaluate the significance of matrix metalloproteinases (MMPs) in predicting the metastatic potential of oral squamous cell carcinomas (SCCs), we compared MMP-2 and -9 expression in 19 metastasizing oral SCCs with that in 25 non-metastasizing cases by immunohistochemistry and gelatin zymography. Immunohistochemistry showed that increased MMP-2 expression was not significantly related to metastasis; increased MMP-9 expression found in oral SCCs was, however, statistically significant (oral SCCs with metastasis, 73.7%; those without metastasis, 36.0%; P
ISSN:1368-8375
1879-0593
DOI:10.1016/S1368-8375(99)00088-3