Does leukocytospermia associate with poor semen parameters and sperm functions in male infertility?: The role of different seminal leukocyte concentrations

To investigate the effect of leukocytospermia on standard semen analysis and sperm function tests such as acrosome reaction, hypoosmotic swelling, antisperm antibody binding and cervical mucus penetration, a prospective clinical study was performed. Two hundred and nineteen male infertility patients...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2000-04, Vol.89 (2), p.185-191
Main Authors: Kaleli, Semih, Öçer, Fahri, Irez, Tülay, Budak, Erdal, Aksu, M.Feridun
Format: Article
Language:English
Subjects:
Acrosome reaction
Adult
Antisperm antibody
Biological and medical sciences
Birth control
Gynecology. Andrology. Obstetrics
Humans
Hypoosmotic swelling test
Infertility, Male - etiology
Infertility, Male - physiopathology
Leukocyte Count
Leukocytes - physiology
Leukocytospermia
Male
Medical sciences
Middle Aged
Reactive Oxygen Species
Semen - cytology
Semen analysis
Spermatozoa - physiology
Sterility. Assisted procreation
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Summary:To investigate the effect of leukocytospermia on standard semen analysis and sperm function tests such as acrosome reaction, hypoosmotic swelling, antisperm antibody binding and cervical mucus penetration, a prospective clinical study was performed. Two hundred and nineteen male infertility patients undergoing investigation and treatment were included in the study. There was a significant association between acrosome reaction positivity and leukocytospermia according to WHO (World Health Organization) criteria. Increased hypoosmotic swelling test score, higher sperm concentration and enhanced acrosome reaction were closely related to leukocytospermia. When the patients were divided into subgroups according to seminal leukocyte concentrations, acrosome reaction and hypoosmotic swelling were observed to be higher in semen samples with higher leukocyte concentrations compared to those with low seminal leukocyte concentration. In addition, higher sperm concentrations were observed in semen samples with increased leukocyte levels compared to semen samples with low leukocyte levels. These results suggest that leukocytospermia may have a favorable effect on some sperm functions at seminal leukocyte concentrations between 1 and 3×10 6/ml.
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(99)00204-3