Skeletal muscle formation in vertebrates

Research in the past year has added to our understanding of the signalling systems that specify myogenic identity in the embryo and of the regulation and roles of MyoD family members. New insights into the movement of muscle precursor cells include the demonstration that Lbx1 is essential for their...

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Bibliographic Details
Published in:Current Opinion in Genetics & Development 2001-08, Vol.11 (4), p.440-448
Main Author: Buckingham, Margaret
Format: Article
Language:English
Subjects:
Animals
Cell Movement - physiology
DNA-Binding Proteins
Gene Expression Regulation
Lbx1 protein
muscle development
Muscle Proteins - genetics
Muscle, Skeletal - cytology
Muscle, Skeletal - embryology
Muscle, Skeletal - metabolism
MyoD protein
Myogenic Regulatory Factor 5
myogenic regulatory factors
Pax3 protein
Pax7 protein
Signal Transduction - physiology
signalling
somites
Trans-Activators
Vertebrates
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Summary:Research in the past year has added to our understanding of the signalling systems that specify myogenic identity in the embryo and of the regulation and roles of MyoD family members. New insights into the movement of muscle precursor cells include the demonstration that Lbx1 is essential for their migration from the somite to some but not all sites of muscle formation elsewhere. Later in development, ras as well as calcineurin signalling is now implicated in the definition of slow versus fast fibre types. The myogenic identity of precursor cells in the adult depends on Pax7, the orthologue of Pax3 which is required for early myogenesis; this finding is of major importance for muscle regeneration and the active field of stem cell research.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00215-X