Fibrinogen, angina and coronary heart disease in a Chinese population

Although fibrinogen is an established risk factor of coronary heart disease (CHD), whether fibrinogen is associated with CHD in Chinese is not clear. This population-based cross-sectional study aimed to analyse this relationship in Hong Kong Chinese. Fibrinogen was measured by the Clauss method in 1...

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Bibliographic Details
Published in:Atherosclerosis 2000-04, Vol.149 (2), p.443-449
Main Authors: Lam, T.H., Liu, L.J., Janus, E.D., Lau, C.P., Hedley, A.J.
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Aging
Analysis of Variance
Angina Pectoris - diagnosis
Angina Pectoris - epidemiology
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Cardiology. Vascular system
China - ethnology
Chinese
Coronary Disease - diagnosis
Coronary Disease - epidemiology
Coronary heart disease
Cross-Sectional Studies
Female
Fibrinogen
Fibrinogen - analysis
Fibrinogen - metabolism
Heart
Hong Kong
Hong Kong - epidemiology
Humans
Incidence
Linear Models
Male
Medical sciences
Middle Aged
Multivariate Analysis
Population Surveillance
Risk Factors
Sex Distribution
Survival Rate
Tropical medicine
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Summary:Although fibrinogen is an established risk factor of coronary heart disease (CHD), whether fibrinogen is associated with CHD in Chinese is not clear. This population-based cross-sectional study aimed to analyse this relationship in Hong Kong Chinese. Fibrinogen was measured by the Clauss method in 1348 men and 1385 women aged 25–74 years. Severity of CHD was defined as most serious if the subjects had medically diagnosed CHD, as less serious if they had angina only, and as normal if they had neither. The prevalence of angina and CHD was respectively 2.4% and 2.2% in men and 3.2% and 2.7% in women. In men the age-adjusted mean fibrinogen concentration was 2.47 (95% confidence interval (CI) 2.43–2.51) g/l in the normal group, 2.65 (95% CI 2.45–2.85) g/l in the angina group, and 2.78 (95% CI 2.56–3.00) g/l in the CHD cases ( P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(99)00347-0