Effects of non-ionic surfactants as permeation enhancers towards piroxicam from the poloxamer gel through rat skins

The enhancing effects of non-ionic surfactants on the permeation of piroxicam from the poloxamer gels were evaluated using Franz diffusion cells fitted with excised rat skins. The effectiveness of penetration enhancers, the ratio of piroxicam flux in the presence or absence of enhancers, was defined...

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Bibliographic Details
Published in:International journal of pharmaceutics 2001-07, Vol.222 (2), p.199-203
Main Authors: Shin, Sang-Chul, Cho, Cheong-Weon, Oh, In-Joon
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Biological and medical sciences
Chemistry, Pharmaceutical
Gels
General pharmacology
Medical sciences
Permeability - drug effects
Permeation
Permeation enhancer
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Piroxicam
Piroxicam - pharmacokinetics
Poloxamer
Poloxamer - pharmacology
Rat skin
Rats
Skin - drug effects
Skin - metabolism
Surface-Active Agents - pharmacology
Surfactants
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Summary:The enhancing effects of non-ionic surfactants on the permeation of piroxicam from the poloxamer gels were evaluated using Franz diffusion cells fitted with excised rat skins. The effectiveness of penetration enhancers, the ratio of piroxicam flux in the presence or absence of enhancers, was defined as the enhancement factor. Among the various non-ionic surfactants tested, polyoxyethylene-2-oleyl ether showed the highest enhancing effects with an enhancement factor of 2.84. To elucidate the mechanisms of the action of enhancers, thermal analysis and histological examinations were carried out. Thermal analysis reveals that various surfactants have different fluidizing effects on stratum corneum. Skin pretreated with the poloxamer 407 gels containing various surfactants showed a loosely layered stratum corneum and wide intercellular space.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(01)00699-8