Seminal arginase activity in infertility

Arginase (Arg) activity in seminal plasma and sperm cells from infertile men and healthy fertile donors was measured. There were no statistically meaningful differences in seminal plasma Arg activity between the two groups whereas sperm cells from oligospermic infertile men had a higher Arg activity...

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Bibliographic Details
Published in:Urolithiasis 2000-01, Vol.28 (1), p.20-23
Main Authors: Elgün, S, Kaçmaz, M, Sen, I, Durak, I
Format: Article
Language:English
Subjects:
Adult
Arginase - analysis
Arginase - metabolism
Humans
Infertility
Infertility, Male - enzymology
Male
Men
Nitric oxide
Semen - chemistry
Semen - enzymology
Spermatozoa - chemistry
Spermatozoa - enzymology
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Summary:Arginase (Arg) activity in seminal plasma and sperm cells from infertile men and healthy fertile donors was measured. There were no statistically meaningful differences in seminal plasma Arg activity between the two groups whereas sperm cells from oligospermic infertile men had a higher Arg activity compared with the controls. Some important correlations were established between sperm count and Arg activity (negative values) and sperm motility and Arg activity (positive values) in both sperm cells and plasma samples from infertile men. Results suggest that the arginine-nitric oxide pathway within sperm cells from oligospermic infertile men is disturbed by enhanced Arg activity. We think that this may play a part in sperm dysfunction and male infertility.
ISSN:0300-5623
2194-7228
1434-0879
2194-7236
DOI:10.1007/s002400050004