Nosocomial Kikuchi's disease : A search for herpesvirus sequences in lymph node tissues using PCR

Histiocytic necrotizing lymphadenitis, also known as Kikuchi's disease (KD), is a rare disease. Fever and lymphadenopathies with characteristic pathologic features are present. The etiology of this disease remains undetermined. Since the disorder is self-limiting, different viruses have been im...

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Bibliographic Details
Published in:Infection 2001-06, Vol.29 (3), p.143-147
Main Authors: MARTINEZ-VAZQUEZ, C, POTEL, C, ANGULO, M, GONZALEZ-CARRERO, J, ALVAREZ, M, TENORIO, A, CID, D, OLIVEIRA, I
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Community-Acquired Infections
Cross Infection
Deoxyribonucleic acid
DNA
DNA, Viral - analysis
Etiology
Female
Herpesviridae - genetics
Herpesvirus
Histiocytic Necrotizing Lymphadenitis - etiology
Histiocytic Necrotizing Lymphadenitis - genetics
Histiocytic Necrotizing Lymphadenitis - virology
Human viral diseases
Humans
Infectious diseases
Lupus Erythematosus, Systemic - complications
Lymph Nodes - virology
Male
Medical sciences
Nosocomial infection
Polymerase Chain Reaction
Sequence Analysis, DNA
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Histiocytic necrotizing lymphadenitis, also known as Kikuchi's disease (KD), is a rare disease. Fever and lymphadenopathies with characteristic pathologic features are present. The etiology of this disease remains undetermined. Since the disorder is self-limiting, different viruses have been implicated as the causative agent. Seven cases of KD were studied. Three patients acquired the disease nosocomially, three had community-acquired KD and one case was associated with systemic lupus erythematosus. PCR was performed on DNA extracted from lymph node tissues in order to detect herpesvirus-specific DNA sequences: herpes simpLex virus type 1 and 2 (HSV1-2), varicella zoster virus (VZV), human cytomegalovirus (HCMV), human herpesvirus 6 (HHV6), Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV8). Viral DNA was not detected in any of the lymph node tissues from the seven cases of KD. We conclude that these herpesviruses were not involved in the etiology of the three cases of nosocomial KD, nor in the other four cases of KD investigated in this study.
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-001-1122-x