Effects of Sclerocarya birrea (A. rich) hochst (anacardiaceae) leaf extracts on calcium signalling in cultured rat skeletal muscle cells

Sclerocarya birrea is a plant used widely to treat many diseases in Burkina Faso, although no scientific data has been reported about its mechanism of action. In the present study the effects of its leaf extracts were investigated on calcium signalling in rat cultured skeletal muscle cells. The resu...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2001-08, Vol.76 (3), p.247-252
Main Authors: Belemtougri, R.G., Constantin, B., Cognard, C., Raymond, G., Sawadogo, L.
Format: Article
Language:English
Subjects:
Anacardiaceae
Animals
Biological and medical sciences
Burkina Faso
Caffeine
Caffeine - pharmacology
Calcium Signaling - drug effects
Cells, Cultured
Cycadopsida - chemistry
Dose-Response Relationship, Drug
Fluorescence
General pharmacology
Intracellular calcium
Medical sciences
Medicine, African Traditional
Muscle, Skeletal - cytology
Muscle, Skeletal - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves - chemistry
Rats
Sarcoplasmic reticulum
Sarcoplasmic Reticulum - drug effects
Sarcoplasmic Reticulum - metabolism
Sclerocarya birrea
Skeletal muscle cells
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Summary:Sclerocarya birrea is a plant used widely to treat many diseases in Burkina Faso, although no scientific data has been reported about its mechanism of action. In the present study the effects of its leaf extracts were investigated on calcium signalling in rat cultured skeletal muscle cells. The results show that the different extracts (crude decoction, aqueous, ethanolic and chloroformic extracts) have significant antagonistic effect on caffeine-induced calcium release from sarcoplasmic reticulum. Crude decoction is the most active followed by ethanolic, aqueous and chloroformic extracts in dose-dependent manner and can partly justify the use of the plant in traditional medicine.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(01)00248-3