Synthesis of 5-fluorouracil-imprinted polymers with multiple hydrogen bonding interactions

The antitumor active compound 5-fluorouracil (5-FU) was used as a target molecule and 5-FU-imprinted polymers were synthesized using 2,6-bis(acrylamido)pyridine and/or 2-(trifluoromethyl)acrylic acid as functional monomers. The 5-FU-imprinted polymers showed a higher affinity for 5-FU than that for...

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Bibliographic Details
Published in:Analyst (London) 2001-01, Vol.126 (6), p.772-774
Main Authors: KUGIMIYA, Akimitsu, MUKAWA, Takasi, TAKEUCHI, Toshifumi
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Fluorouracil - analysis
Fluorouracil - chemistry
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacology. Drug treatments
Polymers
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Summary:The antitumor active compound 5-fluorouracil (5-FU) was used as a target molecule and 5-FU-imprinted polymers were synthesized using 2,6-bis(acrylamido)pyridine and/or 2-(trifluoromethyl)acrylic acid as functional monomers. The 5-FU-imprinted polymers showed a higher affinity for 5-FU than that for 5-FU derivatives. By using both functional monomers simultaneously, the affinity and separation for 5-FU were improved.
ISSN:0003-2654
1364-5528
DOI:10.1039/b010056k