Wavelength dependence of the precision of noninvasive optical measurement of oxy-, deoxy-, and total-hemoglobin concentration

The precision of noninvasive optical measurement of the concentration changes in oxy-, deoxy-, and total-hemoglobin depends on wavelength. For estimating the precision, we calculated the noise level of the concentration changes as the uncertainty in measurements using several wavelength pairs of lig...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2001-06, Vol.28 (6), p.1108-1114
Main Authors: Yamashita, Yuichi, Maki, Atsushi, Koizumi, Hideaki
Format: Article
Language:English
Subjects:
Biological and medical applications
Biophysical Phenomena
Biophysics
blood
brain
Brain - metabolism
brain activity
Error analysis
hemoglobin
Hemoglobins - analysis
Humans
infrared spectroscopy
laser applications in medicine
Laser diodes
Laser spectroscopy
measurement uncertainty
Models, Biological
Neuroscience
Noise propagation
noninvasive optical measurement
Optics and Photonics
Oxyhemoglobins - analysis
Physicists
precision
Proteins
Spectroscopy
Spectroscopy, Near-Infrared - methods
Spectroscopy, Near-Infrared - statistics & numerical data
Visual imaging
wavelength
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Summary:The precision of noninvasive optical measurement of the concentration changes in oxy-, deoxy-, and total-hemoglobin depends on wavelength. For estimating the precision, we calculated the noise level of the concentration changes as the uncertainty in measurements using several wavelength pairs of light. Seven laser diodes (664–848 nm) were used simultaneously for spectroscopic measurement of brain activity during finger motor stimulation. We also used the analysis of error propagation from the uncertainty in direct measurements of absorbance changes to estimate indirectly the uncertainty of concentration changes. The measurement of the concentration changes made using an 830/664-nm pair are two times (oxy-Hb) and six times (deoxy-Hb) more precise than those made using an 830/782-nm pair.
ISSN:0094-2405
2473-4209
DOI:10.1118/1.1373401