14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis

The eventual recovery of patients with acute transverse myelitis is variable and can be difficult to predict on the basis of the presenting clinical and radiographic features. We find that an early accumulation of the 14-3-3 protein occurs exclusively in the cerebrospinal fluid of patients who show...

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Bibliographic Details
Published in:The Lancet (British edition) 2000-03, Vol.355 (9207), p.901-901
Main Authors: Irani, David N, Kerr, Douglas A
Format: Article
Language:English
Subjects:
14-3-3 Proteins
Acute Disease
Biological and medical sciences
Body fluids
Cerebrospinal fluid. Meninges. Spinal cord
Enzyme Inhibitors - analysis
Humans
Medical sciences
Myelitis, Transverse - cerebrospinal fluid
Myelitis, Transverse - diagnosis
Nervous system (semeiology, syndromes)
Neurological disorders
Neurology
Prognosis
Proteins
Proteins - analysis
Tyrosine 3-Monooxygenase
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Description
Summary:The eventual recovery of patients with acute transverse myelitis is variable and can be difficult to predict on the basis of the presenting clinical and radiographic features. We find that an early accumulation of the 14-3-3 protein occurs exclusively in the cerebrospinal fluid of patients who show little or no recovery of neurological function and therefore could serve as a helpful prognostic indicator in this disorder.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(99)04745-5