Overview of the Third International Workshop on Swine Leukocyte Differentiation Antigens

• Published in: Veterinary immunology and immunopathology 2001-07, Vol.80 (1), p.5-23
• Main Authors: Haverson, K, Saalmüller, A, Alvarez, B, Alonso, F, Bailey, M, Bianchi, A.T.J, Boersma, W.J.A, Chen, Z, Davis, W.C, Dominguez, J, Engelhardt, H, Ezquerra, A, Grosmaire, L.S, Hamilton, M.J, Hollemweguer, E, Huang, C.A, Khanna, K.V, Kuebart, G, Lackovic, G, Ledbetter, J.A, Lee, R, Llanes, D, Lunney, J.K, McCullough, K.C, Molitor, T, Nielsen, J, Niewold, T.A, Pescovitz, M.D, Perez de la Lastra, J, Rehakova, Z, Salmon, H, Schnitzlein, W.M, Seebach, J, Simon, A, Sinkora, J, Sinkora, M, Stokes, C.R, Summerfield, A, Sver, L, Thacker, E, Valpotic, I, Yang, H, Zuckermann, F.A, Zwart, R
• Format: Article
• Language: English
• Subjects: ACD antigens; Animals; Antigens; Antigens, CD; Cluster of differentiation (CD); Leukocytes - immunology; Monoclonal antibodies (mAb); Pig; Porcine; Swine; Swine - immunology
• ISSN: 0165-2427; 1873-2534
• DOI: 10.1016/S0165-2427(01)00290-2

The aim of the Third International Workshop on Swine Leukocyte Differentiation Antigens (CD workshop), supported by the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS), was to standardize the assignment of monoclonal antibodies (mAb) reactive with porcine leukocyte differentiation antigens and to define new antibody clusters, using nomenclature in accordance with human and ruminant CD nomenclature, as agreed at the summary meeting of the Second International Swine CD Workshop in Davis, 1995: only mAb with proven reactivity for the orthologous porcine gene product or cross-reactivity for the human gene products, were given the full CD nomenclature, all other allocations were prefixed with ‘w’. As in previous workshops, the overall organization was entrusted to the chair and first author, with support by the chair of the previous workshop and second author. In addition to the existing 26 pig leukocyte CD/SWC determinants established in previous workshops, this workshop established/confirmed another 11 CDs for pig leukocytes, identified by a total of 21 mAb: CD11R1 (2 mAb), CD11R2 (1 mAb), CD11R3 (4 mAb), wCD40 (1 mAb), wCD46 (4 mAb), wCD47 (3 mAb), wCD49d (1 mAb), CD61 (1 mAb), wCD92 (1 mAb), wCD93 (1 mAb) and CD163 (2 mAb).