HIV-1 Drug Resistance Profiles in Children and Adults With Viral Load of <50 Copies/mL Receiving Combination Therapy

CONTEXT The continued release of human immunodeficiency virus type 1 (HIV-1) into plasma at very low levels during highly active antiretroviral therapy (HAART) can be detected using specialized techniques, but the nature and significance of this low-level viremia, especially as related to acquisitio...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2001-07, Vol.286 (2), p.196-207
Main Authors: Hermankova, Monika, Ray, Stuart C, Ruff, Christian, Powell-Davis, Monique, Ingersoll, Roxann, D'Aquila, Richard T, Quinn, Thomas C, Siliciano, Janet D, Siliciano, Robert F, Persaud, Deborah
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiviral agents
Biological and medical sciences
Child
Child, Preschool
Cross-Sectional Studies
Drug resistance
Drug Resistance, Microbial - genetics
Drug therapy
Female
Gene Products, pol - genetics
Genetics
HIV
HIV Infections - drug therapy
HIV Infections - physiopathology
HIV Infections - virology
HIV Protease - genetics
HIV Reverse Transcriptase - genetics
HIV-1 - drug effects
HIV-1 - genetics
Human immunodeficiency virus
Human immunodeficiency virus 1
Humans
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Mutation
Pharmacology. Drug treatments
Plasma
RNA, Viral - blood
Viral Load
Viremia - diagnosis
Viremia - physiopathology
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Summary:CONTEXT The continued release of human immunodeficiency virus type 1 (HIV-1) into plasma at very low levels during highly active antiretroviral therapy (HAART) can be detected using specialized techniques, but the nature and significance of this low-level viremia, especially as related to acquisition of drug resistance mutations, are unclear. OBJECTIVE To determine genetic resistance profiles of low-level plasma HIV-1 in patients with prolonged viral suppression (
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.286.2.196