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Dietary Supplementation with Highly Purified Eicosapentaenoic Acid and Docosahexaenoic Acid Does Not Influence PAI-1 Activity
Impaired fibrinolysis due to elevated levels of plasminogen activator inhibitor type 1 (PAI-1) is a risk factor for atherothrombotic disease. Many studies have reported a positive correlation between serum triglycerides and PAI-1 activity. Dietary intervention with very long n-3 fatty acids from mar...
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| Published in: | Thrombosis research 2000-04, Vol.98 (2), p.123-132 |
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| creator | Hansen, John-Bjarne Grimsgaard, Sameline Nordøy, Arne Bønaa, Kaare H. |
| description | Impaired fibrinolysis due to elevated levels of plasminogen activator inhibitor type 1 (PAI-1) is a risk factor for atherothrombotic disease. Many studies have reported a positive correlation between serum triglycerides and PAI-1 activity. Dietary intervention with very long n-3 fatty acids from marine sources is known to decrease serum triglycerides, but an adverse increase in PAI-1 activity has been reported in some studies. A double blind, placebo controlled study was conducted among 224 middle-aged (ages 36–56), healthy, non-smoking men in which the participants were randomly assigned to daily supplementation with 3.8 g eicosapentaenoic acid/d, 3.6 g docosahexaenoic acid/d, or 4.0 g corn oil/d (placebo) for 7 weeks. PAI-1 activity increased by 2.35±6.24 U/ml (28%), 1.15±6.74 U/ml (14%), and 1.33±5.64 U/ml (22%) during dietary supplementation with eicosapentaenoic acid, docosahexaenoic acid, and corn oil, respectively, but the changes were not significantly different between groups
p=0.43
. There was no relationship between change in concentrations of serum triglycerides or phospholipid n-3 fatty acids and change in PAI-1 activity. At baseline, analysis was performed to investigate the influence of dietary lipids, blood lipids, and serum fatty acids on plasma concentrations of PAI-1 activity. Dietary intake of saturated fat correlated directly with PAI-1 both in crude analysis
r=0,14, p |
| doi_str_mv | 10.1016/S0049-3848(99)00223-6 |
| format | article |
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p=0.43
. There was no relationship between change in concentrations of serum triglycerides or phospholipid n-3 fatty acids and change in PAI-1 activity. At baseline, analysis was performed to investigate the influence of dietary lipids, blood lipids, and serum fatty acids on plasma concentrations of PAI-1 activity. Dietary intake of saturated fat correlated directly with PAI-1 both in crude analysis
r=0,14, p<0.05
and after adjustment for age and body mass index (kg/m
2)
r=0.20, p<0.01
. Furthermore, PAI-1 was associated with body mass index
r=0.32, p<0.001
, apo-B100
r=0.27, p<0.001
, serum triglycerides
r=0.31, p<0.001
, and the concentration of n-6 polyunsaturated fatty acids
r=0.22, p<0.01
in serum. In a multiple regression analysis, 21% of the variation in PAI-1 activity could be explained by these variables. Plasma PAI-1 activity did not correlate with dietary intake or serum concentrations of n-3 polyunsaturated fatty acids. In a review of 17 trials, including 935 subjects that assessed the effect of n-3 fatty acids on PAI-1 activity, an overall 17.7% increase in PAI-1 activity was estimated by n-3 supplementation. However, only two studies were able to demonstrate a significant increase in PAI-1 attributable to n-3 fatty acid supplementation. We conclude that there is no strong evidence for an unfavourable, clinically relevant effect of n-3 fatty acids on PAI-1 activity in plasma.]]></description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/S0049-3848(99)00223-6</identifier><identifier>PMID: 10713313</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Adult ; Arteriosclerosis - blood ; Arteriosclerosis - etiology ; Arteriosclerosis - prevention & control ; Biological and medical sciences ; Dietary Fats, Unsaturated - administration & dosage ; Dietary Fats, Unsaturated - adverse effects ; Diseases of the cardiovascular system ; Docosahexaenoic acid ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - adverse effects ; Double-Blind Method ; Eicosapentaenoic acid ; Eicosapentaenoic Acid - administration & dosage ; Eicosapentaenoic Acid - adverse effects ; Female ; Fibrinolysis ; Humans ; Lipids - blood ; Male ; Medical sciences ; Middle Aged ; n-3 fatty acids ; PAI-1 activity ; Plasminogen Activator Inhibitor 1 - blood ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Serum lipids ; Thrombosis - blood ; Thrombosis - etiology ; Thrombosis - prevention & control ; Triglycerides - blood</subject><ispartof>Thrombosis research, 2000-04, Vol.98 (2), p.123-132</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-f51a4e8ee38f9b76068b7c16ccced95722a9a7b721545631151b5f4518021ef43</citedby><cites>FETCH-LOGICAL-c390t-f51a4e8ee38f9b76068b7c16ccced95722a9a7b721545631151b5f4518021ef43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1344334$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10713313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hansen, John-Bjarne</creatorcontrib><creatorcontrib>Grimsgaard, Sameline</creatorcontrib><creatorcontrib>Nordøy, Arne</creatorcontrib><creatorcontrib>Bønaa, Kaare H.</creatorcontrib><title>Dietary Supplementation with Highly Purified Eicosapentaenoic Acid and Docosahexaenoic Acid Does Not Influence PAI-1 Activity</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description><![CDATA[Impaired fibrinolysis due to elevated levels of plasminogen activator inhibitor type 1 (PAI-1) is a risk factor for atherothrombotic disease. Many studies have reported a positive correlation between serum triglycerides and PAI-1 activity. Dietary intervention with very long n-3 fatty acids from marine sources is known to decrease serum triglycerides, but an adverse increase in PAI-1 activity has been reported in some studies. A double blind, placebo controlled study was conducted among 224 middle-aged (ages 36–56), healthy, non-smoking men in which the participants were randomly assigned to daily supplementation with 3.8 g eicosapentaenoic acid/d, 3.6 g docosahexaenoic acid/d, or 4.0 g corn oil/d (placebo) for 7 weeks. PAI-1 activity increased by 2.35±6.24 U/ml (28%), 1.15±6.74 U/ml (14%), and 1.33±5.64 U/ml (22%) during dietary supplementation with eicosapentaenoic acid, docosahexaenoic acid, and corn oil, respectively, but the changes were not significantly different between groups
p=0.43
. There was no relationship between change in concentrations of serum triglycerides or phospholipid n-3 fatty acids and change in PAI-1 activity. At baseline, analysis was performed to investigate the influence of dietary lipids, blood lipids, and serum fatty acids on plasma concentrations of PAI-1 activity. Dietary intake of saturated fat correlated directly with PAI-1 both in crude analysis
r=0,14, p<0.05
and after adjustment for age and body mass index (kg/m
2)
r=0.20, p<0.01
. Furthermore, PAI-1 was associated with body mass index
r=0.32, p<0.001
, apo-B100
r=0.27, p<0.001
, serum triglycerides
r=0.31, p<0.001
, and the concentration of n-6 polyunsaturated fatty acids
r=0.22, p<0.01
in serum. In a multiple regression analysis, 21% of the variation in PAI-1 activity could be explained by these variables. Plasma PAI-1 activity did not correlate with dietary intake or serum concentrations of n-3 polyunsaturated fatty acids. In a review of 17 trials, including 935 subjects that assessed the effect of n-3 fatty acids on PAI-1 activity, an overall 17.7% increase in PAI-1 activity was estimated by n-3 supplementation. However, only two studies were able to demonstrate a significant increase in PAI-1 attributable to n-3 fatty acid supplementation. We conclude that there is no strong evidence for an unfavourable, clinically relevant effect of n-3 fatty acids on PAI-1 activity in plasma.]]></description><subject>Adult</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - etiology</subject><subject>Arteriosclerosis - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Dietary Fats, Unsaturated - administration & dosage</subject><subject>Dietary Fats, Unsaturated - adverse effects</subject><subject>Diseases of the cardiovascular system</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Docosahexaenoic Acids - adverse effects</subject><subject>Double-Blind Method</subject><subject>Eicosapentaenoic acid</subject><subject>Eicosapentaenoic Acid - administration & dosage</subject><subject>Eicosapentaenoic Acid - adverse effects</subject><subject>Female</subject><subject>Fibrinolysis</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>n-3 fatty acids</subject><subject>PAI-1 activity</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Serum lipids</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - prevention & control</subject><subject>Triglycerides - blood</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkMFu1DAQhi0EotvCI4B8QBU9BDxxHMcntOqWdqUKKhXOluOMWaNsHGKnZQ99d5LuCnrjNIf_-2dGHyFvgH0ABuXHW8YKlfGqqN4rdcZYnvOsfEYWUEmV5YXMn5PFX-SIHMf4kzGQoMRLcgRMAufAF-Rh5TGZYUdvx75vcYtdMsmHjt77tKFX_sem3dGbcfDOY0MvvA3R9DOEXfCWLq1vqOkaugpzssHfT4NVwEi_hETXnWtH7CzSm-U6gylN_s6n3Svywpk24uvDPCHfP198O7_Krr9ers-X15nliqXMCTAFVoi8cqqWJSurWloorbXYKCHz3Cgja5mDKETJAQTUwhUCKpYDuoKfkNP93n4Iv0aMSW99tNi2psMwRi1hcqN4NYFiD9ohxDig0_3gt5MfDUzP3vWjdz1L1UrpR--6nHpvDwfGeovNk9Ze9AS8OwAmWtO6wXTWx38cLwrO50c_7TGcbNx5HHS0fhbX-AFt0k3w__nkD7TunzY</recordid><startdate>20000415</startdate><enddate>20000415</enddate><creator>Hansen, John-Bjarne</creator><creator>Grimsgaard, Sameline</creator><creator>Nordøy, Arne</creator><creator>Bønaa, Kaare H.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000415</creationdate><title>Dietary Supplementation with Highly Purified Eicosapentaenoic Acid and Docosahexaenoic Acid Does Not Influence PAI-1 Activity</title><author>Hansen, John-Bjarne ; Grimsgaard, Sameline ; Nordøy, Arne ; Bønaa, Kaare H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-f51a4e8ee38f9b76068b7c16ccced95722a9a7b721545631151b5f4518021ef43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - etiology</topic><topic>Arteriosclerosis - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Dietary Fats, Unsaturated - administration & dosage</topic><topic>Dietary Fats, Unsaturated - adverse effects</topic><topic>Diseases of the cardiovascular system</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - adverse effects</topic><topic>Double-Blind Method</topic><topic>Eicosapentaenoic acid</topic><topic>Eicosapentaenoic Acid - administration & dosage</topic><topic>Eicosapentaenoic Acid - adverse effects</topic><topic>Female</topic><topic>Fibrinolysis</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>n-3 fatty acids</topic><topic>PAI-1 activity</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Serum lipids</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - prevention & control</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hansen, John-Bjarne</creatorcontrib><creatorcontrib>Grimsgaard, Sameline</creatorcontrib><creatorcontrib>Nordøy, Arne</creatorcontrib><creatorcontrib>Bønaa, Kaare H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hansen, John-Bjarne</au><au>Grimsgaard, Sameline</au><au>Nordøy, Arne</au><au>Bønaa, Kaare H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Supplementation with Highly Purified Eicosapentaenoic Acid and Docosahexaenoic Acid Does Not Influence PAI-1 Activity</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2000-04-15</date><risdate>2000</risdate><volume>98</volume><issue>2</issue><spage>123</spage><epage>132</epage><pages>123-132</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract><![CDATA[Impaired fibrinolysis due to elevated levels of plasminogen activator inhibitor type 1 (PAI-1) is a risk factor for atherothrombotic disease. Many studies have reported a positive correlation between serum triglycerides and PAI-1 activity. Dietary intervention with very long n-3 fatty acids from marine sources is known to decrease serum triglycerides, but an adverse increase in PAI-1 activity has been reported in some studies. A double blind, placebo controlled study was conducted among 224 middle-aged (ages 36–56), healthy, non-smoking men in which the participants were randomly assigned to daily supplementation with 3.8 g eicosapentaenoic acid/d, 3.6 g docosahexaenoic acid/d, or 4.0 g corn oil/d (placebo) for 7 weeks. PAI-1 activity increased by 2.35±6.24 U/ml (28%), 1.15±6.74 U/ml (14%), and 1.33±5.64 U/ml (22%) during dietary supplementation with eicosapentaenoic acid, docosahexaenoic acid, and corn oil, respectively, but the changes were not significantly different between groups
p=0.43
. There was no relationship between change in concentrations of serum triglycerides or phospholipid n-3 fatty acids and change in PAI-1 activity. At baseline, analysis was performed to investigate the influence of dietary lipids, blood lipids, and serum fatty acids on plasma concentrations of PAI-1 activity. Dietary intake of saturated fat correlated directly with PAI-1 both in crude analysis
r=0,14, p<0.05
and after adjustment for age and body mass index (kg/m
2)
r=0.20, p<0.01
. Furthermore, PAI-1 was associated with body mass index
r=0.32, p<0.001
, apo-B100
r=0.27, p<0.001
, serum triglycerides
r=0.31, p<0.001
, and the concentration of n-6 polyunsaturated fatty acids
r=0.22, p<0.01
in serum. In a multiple regression analysis, 21% of the variation in PAI-1 activity could be explained by these variables. Plasma PAI-1 activity did not correlate with dietary intake or serum concentrations of n-3 polyunsaturated fatty acids. In a review of 17 trials, including 935 subjects that assessed the effect of n-3 fatty acids on PAI-1 activity, an overall 17.7% increase in PAI-1 activity was estimated by n-3 supplementation. However, only two studies were able to demonstrate a significant increase in PAI-1 attributable to n-3 fatty acid supplementation. We conclude that there is no strong evidence for an unfavourable, clinically relevant effect of n-3 fatty acids on PAI-1 activity in plasma.]]></abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>10713313</pmid><doi>10.1016/S0049-3848(99)00223-6</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-3848 |
| ispartof | Thrombosis research, 2000-04, Vol.98 (2), p.123-132 |
| issn | 0049-3848 1879-2472 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71001938 |
| source | ScienceDirect Journals |
| subjects | Adult Arteriosclerosis - blood Arteriosclerosis - etiology Arteriosclerosis - prevention & control Biological and medical sciences Dietary Fats, Unsaturated - administration & dosage Dietary Fats, Unsaturated - adverse effects Diseases of the cardiovascular system Docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - adverse effects Double-Blind Method Eicosapentaenoic acid Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - adverse effects Female Fibrinolysis Humans Lipids - blood Male Medical sciences Middle Aged n-3 fatty acids PAI-1 activity Plasminogen Activator Inhibitor 1 - blood Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Serum lipids Thrombosis - blood Thrombosis - etiology Thrombosis - prevention & control Triglycerides - blood |
| title | Dietary Supplementation with Highly Purified Eicosapentaenoic Acid and Docosahexaenoic Acid Does Not Influence PAI-1 Activity |
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