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Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures

Lithospermum erythrorhizon cells cultured in pigment production (M-9) medium produced lithospermic acid B, a dimerized caffeic acid ester derivative, in quantities similar to the production of shikonin. The cells also produced a related dimer, (+)-rabdosiin. In Linsmaier–Skoog liquid medium, which s...

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Published in:	Phytochemistry (Oxford) 2000-03, Vol.53 (6), p.651-657
Main Authors:	Yamamoto, Hirobumi, Inoue, Kenichiro, Yazaki, Kazufumi
Format:	Article
Language:	English
Subjects:	(+)-Rabdosiin Benzofurans - chemistry Benzofurans - metabolism Biological and medical sciences Biotechnology Boraginaceae Caffeic acid oligomers Caffeic Acids - chemistry Caffeic Acids - metabolism Cell suspension cultures Cells, Cultured Depsides Dimerization Fundamental and applied biological sciences. Psychology Lignans Lithospermic acid B Lithospermum erythrorhizon Magnetic Resonance Spectroscopy Naphthoquinones - chemistry Naphthoquinones - metabolism Plant physiology and development Plants - chemistry Plants - metabolism Secondary metabolite production Shikonin Tissue cultures, protoplasts
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description	Lithospermum erythrorhizon cells cultured in pigment production (M-9) medium produced lithospermic acid B, a dimerized caffeic acid ester derivative, in quantities similar to the production of shikonin. The cells also produced a related dimer, (+)-rabdosiin. In Linsmaier–Skoog liquid medium, which suppresses shikonin production, both lithospermic acid B and (+)-rabdosiin were still formed. Lithospermic acid, a caffeic acid–rosmarinic acid conjugate, was isolated as a main constituent in Lithospermum hairy root cultures. In the aerial parts of L. erythrorhizon, the content of these phenylpropanoid oligomers was relatively low compared to that of rosmarinic acid.
doi_str_mv	10.1016/S0031-9422(99)00623-8
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Psychology ; Lignans ; Lithospermic acid B ; Lithospermum erythrorhizon ; Magnetic Resonance Spectroscopy ; Naphthoquinones - chemistry ; Naphthoquinones - metabolism ; Plant physiology and development ; Plants - chemistry ; Plants - metabolism ; Secondary metabolite production ; Shikonin ; Tissue cultures, protoplasts</subject><ispartof>Phytochemistry (Oxford), 2000-03, Vol.53 (6), p.651-657</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-1b53945d23d7a1989fc5e06f34175366c2643e1edc0945e09e645b76a8e3bd223</citedby><cites>FETCH-LOGICAL-c456t-1b53945d23d7a1989fc5e06f34175366c2643e1edc0945e09e645b76a8e3bd223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1288186$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10746877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Hirobumi</creatorcontrib><creatorcontrib>Inoue, Kenichiro</creatorcontrib><creatorcontrib>Yazaki, Kazufumi</creatorcontrib><title>Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>Lithospermum erythrorhizon cells cultured in pigment production (M-9) medium produced lithospermic acid B, a dimerized caffeic acid ester derivative, in quantities similar to the production of shikonin. 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subjects	(+)-Rabdosiin Benzofurans - chemistry Benzofurans - metabolism Biological and medical sciences Biotechnology Boraginaceae Caffeic acid oligomers Caffeic Acids - chemistry Caffeic Acids - metabolism Cell suspension cultures Cells, Cultured Depsides Dimerization Fundamental and applied biological sciences. Psychology Lignans Lithospermic acid B Lithospermum erythrorhizon Magnetic Resonance Spectroscopy Naphthoquinones - chemistry Naphthoquinones - metabolism Plant physiology and development Plants - chemistry Plants - metabolism Secondary metabolite production Shikonin Tissue cultures, protoplasts
title	Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures
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