How Echinococcus granulosus Deals with Complement

Here, Ana Marı́a Ferreira and colleagues discuss the interplay between the larval stages of Echinococcus granulosus and an important effector arm of immunity: the host complement system. During early infection, the parasite activates complement, and hence complement-dependent inflammatory responses....

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Bibliographic Details
Published in:Parasitology today (Regular ed.) 2000-04, Vol.16 (4), p.168-172
Main Authors: Ferreira, A.M., Irigoı́n, F., Breijo, M., Sim, R.B., Dı́az, A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cattle
Complement
Complement Activation
Echinococcosis - immunology
Echinococcus
Echinococcus - growth & development
Echinococcus - immunology
Echinococcus granulosus
Fundamental and applied biological sciences. Psychology
Host-Parasite Interactions - immunology
Hydatid disease
Immune invasion
Inflammation
Life cycle. Host-agent relationship. Pathogenesis
Mice
Protozoa
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Summary:Here, Ana Marı́a Ferreira and colleagues discuss the interplay between the larval stages of Echinococcus granulosus and an important effector arm of immunity: the host complement system. During early infection, the parasite activates complement, and hence complement-dependent inflammatory responses. However, on differentiation into the hydatid cyst, the parasite exposes to the host a structure – the cyst wall – that does not activate complement strongly. Mechanisms inhibiting complement activation on the cyst wall have been elucidated, contributing to the understanding of how this large, persistent, tissue-dwelling pathogen controls the inflammatory response.
ISSN:0169-4758
1873-1473
DOI:10.1016/S0169-4758(99)01625-7