Screening for viral markers in volunteer and replacement blood donors in West Africa

Background and Objectives West Africa is a highly endemic area for viral infections. The prevalence of five viral markers was determined in Ghanaian blood donors. Materials and Methods Replacement and volunteer blood donors were screened using enzyme immunoassays (EIAs) for hepatitis B surface antig...

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Bibliographic Details
Published in:Vox sanguinis 2001-04, Vol.80 (3), p.142-147
Main Authors: Sarkodie, F., Adarkwa, M., Adu-Sarkodie, Y., Candotti, D., Acheampong, J. W., Allain, J. P.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antibodies, Viral - blood
Antigens, Viral - blood
Biological and medical sciences
Blood Donors
blood screening
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Enzyme-Linked Immunosorbent Assay
Family
Female
Ghana - epidemiology
HBV
HCV
Hepatitis B Surface Antigens - blood
Hepatitis C Antibodies - blood
HIV
HIV Antibodies - blood
HIV Core Protein p24 - blood
HIV Seroprevalence
HTLV-I Antibodies - blood
HTLV-II Antibodies - blood
Humans
Male
Mass Screening
Medical sciences
Middle Aged
RNA, Viral - blood
Seroepidemiologic Studies
Transfusion Reaction
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Viremia - blood
Viremia - diagnosis
Viremia - epidemiology
Viremia - prevention & control
Viremia - transmission
Volunteers
West Africa
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Summary:Background and Objectives West Africa is a highly endemic area for viral infections. The prevalence of five viral markers was determined in Ghanaian blood donors. Materials and Methods Replacement and volunteer blood donors were screened using enzyme immunoassays (EIAs) for hepatitis B surface antigen (HBsAg), human immunodeficiency virus antibodies (anti‐HIV), HIV p24 antigen, human T‐cell lymphocytotrophic virus‐I and ‐II antibodies (anti‐HTLV‐I/II) and hepatitis C virus antibodies (anti‐HCV). Results HBsAg was present at an equally high frequency (15%) in young volunteer (median age 18 years) and older replacement (median age 33 years) blood donors. In contrast, the prevalence of anti‐HIV and anti‐HCV was significantly higher in replacement blood donors (2·4 and 0·3%, respectively, P 
ISSN:0042-9007
1423-0410
DOI:10.1046/j.1423-0410.2001.00023.x