Glutathione supplementation and training increases myocardial resistance to ischemia-reperfusion in vivo

Interdisciplinary Nutritional Science Program, Department of Kinesiology, University of Wisconsin, Madison, Wisconsin 53706 The present study examined the effects of oral reduced glutathione (GSH) supplementation in conjunction with endurance training on contractile function, antioxidant defense, an...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2001-08, Vol.281 (2), p.H679-H688
Main Authors: Ramires, P. R, Ji, L. L
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Blood Pressure
Female
Glutathione - administration & dosage
Myocardial Ischemia - metabolism
Myocardial Ischemia - physiopathology
Myocardial Ischemia - prevention & control
Myocardial Reperfusion Injury - metabolism
Myocardial Reperfusion Injury - physiopathology
Myocardial Reperfusion Injury - prevention & control
Oxidative Stress
Physical Conditioning, Animal
Rats
Rats, Sprague-Dawley
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Summary:Interdisciplinary Nutritional Science Program, Department of Kinesiology, University of Wisconsin, Madison, Wisconsin 53706 The present study examined the effects of oral reduced glutathione (GSH) supplementation in conjunction with endurance training on contractile function, antioxidant defense, and oxidative damage in response to ischemia-reperfusion (I/R) in rat hearts. Female Sprague-Dawley rats (age 4 mo, n  = 72) were randomly assigned to a treadmill-trained (T; 25 m/min, 15% grade, for 75 min/day, 5 days/wk, for 10 wk) or untrained (U) group. Each group was further divided into rats receiving 5 g GSH/kg diet during the final 17   days of training (GSH-S) and control (C) groups. One-half of each group of rats was subjected to I/R by surgical occlusion of the main coronary artery for 45 min, followed by 30-min reperfusion or sham operation. Left ventriclar (LV) peak systolic pressure (LVSP) and contractility (+dP/d t ), measured with a catheter inserted into the LV via the carotid artery, decreased with I/R in all groups ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.2001.281.2.h679