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Color Doppler imaging of untreated and irradiated choroidal melanomas
We examined untreated and irradiated choroidal melanomas with color Doppler imaging (CDI), a noninvasive method providing quantitative measures of blood flow, to determine if the tumor vessel damage associated with irradiation can be detected using this technology. CDI was performed on 122 untreated...
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| Published in: | European journal of ophthalmology 2001-04, Vol.11 (2), p.150-155 |
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| container_end_page | 155 |
| container_issue | 2 |
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| container_title | European journal of ophthalmology |
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| creator | REGAN, S EGAN, K. M HART, L GRAGOUDAS, E. S |
| description | We examined untreated and irradiated choroidal melanomas with color Doppler imaging (CDI), a noninvasive method providing quantitative measures of blood flow, to determine if the tumor vessel damage associated with irradiation can be detected using this technology.
CDI was performed on 122 untreated and 76 previously irradiated tumors using a Q2000 color Doppler ultrasound unit. Spectral analysis was performed on all detectable vascular regions within the tumor to obtain estimates of the peak systolic and end diastolic flow velocities and resistive index ((syst-diast)/syst).
Vessels were detected in 93% of the untreated tumors and in 63% of the treated tumors (p |
| doi_str_mv | 10.1177/112067210101100208 |
| format | article |
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CDI was performed on 122 untreated and 76 previously irradiated tumors using a Q2000 color Doppler ultrasound unit. Spectral analysis was performed on all detectable vascular regions within the tumor to obtain estimates of the peak systolic and end diastolic flow velocities and resistive index ((syst-diast)/syst).
Vessels were detected in 93% of the untreated tumors and in 63% of the treated tumors (p<0.001, X2), and the median number of vascular regions found was higher among untreated tumors (3 vs 1, p=0.001, Wilcoxon Rank Sum). The effect of treatment status on the detection of tumor vessels was significant (p=0.039), controlling for age, sex, largest tumor pretreatment diameter, and tumor height at CDI in a logistic regression model. Mean resistive index was lower in the untreated tumors (0.53 vs 0.58, p=0.0050), controlling for tumor height and other covariates in an analysis of variance.
On examination with CDI, irradiated tumors had fewer detectable vascular regions and greater resistance to flow than untreated tumors, a pattern consistent with known radiation effects.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/112067210101100208</identifier><identifier>PMID: 11456016</identifier><language>eng</language><publisher>Milano: Wichtig</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood Flow Velocity ; Choroid Neoplasms - blood supply ; Choroid Neoplasms - diagnostic imaging ; Choroid Neoplasms - radiotherapy ; Female ; Humans ; Laser-Doppler Flowmetry ; Male ; Medical sciences ; Melanoma - blood supply ; Melanoma - diagnostic imaging ; Melanoma - radiotherapy ; Middle Aged ; Neovascularization, Pathologic - diagnostic imaging ; Neovascularization, Pathologic - pathology ; Ophthalmology ; Protons ; Radiotherapy, High-Energy ; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus ; Ultrasonography, Doppler, Color</subject><ispartof>European journal of ophthalmology, 2001-04, Vol.11 (2), p.150-155</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-9b3291a0aebb9faab4397eb69e1b2bb5d2b184060107996a72e0b357f561803a3</citedby><cites>FETCH-LOGICAL-c372t-9b3291a0aebb9faab4397eb69e1b2bb5d2b184060107996a72e0b357f561803a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1026916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11456016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>REGAN, S</creatorcontrib><creatorcontrib>EGAN, K. M</creatorcontrib><creatorcontrib>HART, L</creatorcontrib><creatorcontrib>GRAGOUDAS, E. S</creatorcontrib><title>Color Doppler imaging of untreated and irradiated choroidal melanomas</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>We examined untreated and irradiated choroidal melanomas with color Doppler imaging (CDI), a noninvasive method providing quantitative measures of blood flow, to determine if the tumor vessel damage associated with irradiation can be detected using this technology.
CDI was performed on 122 untreated and 76 previously irradiated tumors using a Q2000 color Doppler ultrasound unit. Spectral analysis was performed on all detectable vascular regions within the tumor to obtain estimates of the peak systolic and end diastolic flow velocities and resistive index ((syst-diast)/syst).
Vessels were detected in 93% of the untreated tumors and in 63% of the treated tumors (p<0.001, X2), and the median number of vascular regions found was higher among untreated tumors (3 vs 1, p=0.001, Wilcoxon Rank Sum). The effect of treatment status on the detection of tumor vessels was significant (p=0.039), controlling for age, sex, largest tumor pretreatment diameter, and tumor height at CDI in a logistic regression model. Mean resistive index was lower in the untreated tumors (0.53 vs 0.58, p=0.0050), controlling for tumor height and other covariates in an analysis of variance.
On examination with CDI, irradiated tumors had fewer detectable vascular regions and greater resistance to flow than untreated tumors, a pattern consistent with known radiation effects.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Choroid Neoplasms - blood supply</subject><subject>Choroid Neoplasms - diagnostic imaging</subject><subject>Choroid Neoplasms - radiotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Laser-Doppler Flowmetry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - blood supply</subject><subject>Melanoma - diagnostic imaging</subject><subject>Melanoma - radiotherapy</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - diagnostic imaging</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Ophthalmology</subject><subject>Protons</subject><subject>Radiotherapy, High-Energy</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><subject>Ultrasonography, Doppler, Color</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNplkE9LxDAQxYMorq5-AQ_Sg3irZtI22RxlXf_Aghc9l0mbrpG0qUl78NubugUFmcPMwG8ebx4hF0BvAIS4BWCUCwY0FlDK6OqAnIBgecop8MM4RyCdiAU5DeFjQmTOjskCIC8m5oRs1s46n9y7vrfaJ6bFnel2iWuSsRu8xkHXCXZ1YrzH2vys1bvzztRok1Zb7FyL4YwcNWiDPp_7krw9bF7XT-n25fF5fbdNq0ywIZUqYxKQolZKNogqz6TQiksNiilV1EzBKqfRGRVSchRMU5UVoik4rGiG2ZJc73V77z5HHYayNaHSNtrQbgyliDFIIWkE2R6svAvB66bsffzNf5VAyym88n948ehyVh9Vq-vfkzmtCFzNAIYKbeOxq0z4I824jNg36ud1OA</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>REGAN, S</creator><creator>EGAN, K. M</creator><creator>HART, L</creator><creator>GRAGOUDAS, E. S</creator><general>Wichtig</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Color Doppler imaging of untreated and irradiated choroidal melanomas</title><author>REGAN, S ; EGAN, K. M ; HART, L ; GRAGOUDAS, E. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-9b3291a0aebb9faab4397eb69e1b2bb5d2b184060107996a72e0b357f561803a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Choroid Neoplasms - blood supply</topic><topic>Choroid Neoplasms - diagnostic imaging</topic><topic>Choroid Neoplasms - radiotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Laser-Doppler Flowmetry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - blood supply</topic><topic>Melanoma - diagnostic imaging</topic><topic>Melanoma - radiotherapy</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - diagnostic imaging</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Ophthalmology</topic><topic>Protons</topic><topic>Radiotherapy, High-Energy</topic><topic>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</topic><topic>Ultrasonography, Doppler, Color</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>REGAN, S</creatorcontrib><creatorcontrib>EGAN, K. M</creatorcontrib><creatorcontrib>HART, L</creatorcontrib><creatorcontrib>GRAGOUDAS, E. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>REGAN, S</au><au>EGAN, K. M</au><au>HART, L</au><au>GRAGOUDAS, E. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Color Doppler imaging of untreated and irradiated choroidal melanomas</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>11</volume><issue>2</issue><spage>150</spage><epage>155</epage><pages>150-155</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>We examined untreated and irradiated choroidal melanomas with color Doppler imaging (CDI), a noninvasive method providing quantitative measures of blood flow, to determine if the tumor vessel damage associated with irradiation can be detected using this technology.
CDI was performed on 122 untreated and 76 previously irradiated tumors using a Q2000 color Doppler ultrasound unit. Spectral analysis was performed on all detectable vascular regions within the tumor to obtain estimates of the peak systolic and end diastolic flow velocities and resistive index ((syst-diast)/syst).
Vessels were detected in 93% of the untreated tumors and in 63% of the treated tumors (p<0.001, X2), and the median number of vascular regions found was higher among untreated tumors (3 vs 1, p=0.001, Wilcoxon Rank Sum). The effect of treatment status on the detection of tumor vessels was significant (p=0.039), controlling for age, sex, largest tumor pretreatment diameter, and tumor height at CDI in a logistic regression model. Mean resistive index was lower in the untreated tumors (0.53 vs 0.58, p=0.0050), controlling for tumor height and other covariates in an analysis of variance.
On examination with CDI, irradiated tumors had fewer detectable vascular regions and greater resistance to flow than untreated tumors, a pattern consistent with known radiation effects.</abstract><cop>Milano</cop><pub>Wichtig</pub><pmid>11456016</pmid><doi>10.1177/112067210101100208</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1120-6721 1724-6016 |
| language | eng |
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| source | SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list) |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Blood Flow Velocity Choroid Neoplasms - blood supply Choroid Neoplasms - diagnostic imaging Choroid Neoplasms - radiotherapy Female Humans Laser-Doppler Flowmetry Male Medical sciences Melanoma - blood supply Melanoma - diagnostic imaging Melanoma - radiotherapy Middle Aged Neovascularization, Pathologic - diagnostic imaging Neovascularization, Pathologic - pathology Ophthalmology Protons Radiotherapy, High-Energy Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus Ultrasonography, Doppler, Color |
| title | Color Doppler imaging of untreated and irradiated choroidal melanomas |
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