Single molecule nanobioscience

In recent years, the rapid development and progress of single-molecule detection techniques have opened up a new era of biological research. The advantage of single-molecule studies is that data are not obscured by the ensemble-averaged measurements inherent in classical biochemical experiments. The...

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Bibliographic Details
Published in:Trends in Biochemical Sciences 2001-07, Vol.26 (7), p.438-444
Main Authors: Ishijima, Akihiko, Yanagida, Toshio
Format: Article
Language:English
Subjects:
Actins - chemistry
Adenosine Triphosphatases - metabolism
Animals
Biotechnology - instrumentation
Biotechnology - methods
cell signal
DNA - ultrastructure
Humans
Ion Channels - chemistry
kinesin
Kinesin - chemistry
Microscopy, Fluorescence
Models, Biological
molecular motor
myosin
Myosins - chemistry
nanomanipulation
optical tweezers
Signal Transduction
single molecular imaging
total internal reflection fluorescence microscopy
Transcription, Genetic
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Summary:In recent years, the rapid development and progress of single-molecule detection techniques have opened up a new era of biological research. The advantage of single-molecule studies is that data are not obscured by the ensemble-averaged measurements inherent in classical biochemical experiments. These techniques are shedding light on the dynamic and mechanistic properties of molecular machines, both in vivo and in vitro. This review summarizes the single-molecule experiments that have been designed to investigate molecular motors, enzyme reactions, protein dynamics, DNA transcription and cell signaling.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(01)01860-6