Casein Kinase I: From Obscurity to Center Stage

The casein kinase I (CKI) family of protein kinases is a group of highly related, ubiquitously expressed serine/threonine kinases found in all eukaryotic organisms from protozoa to man. Recent advances in diverse fields, including developmental biology and chronobiology, have elucidated roles for CK...

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Bibliographic Details
Published in:IUBMB life 2001-02, Vol.51 (2), p.73-78
Main Authors: Vielhaber, Erica, Virshup, David M.
Format: Article
Language:English
Subjects:
Alzheimer Disease - pathology
Alzheimer'S
Animals
Casein
Casein Kinases
Circadian
Circadian Rhythm - physiology
Disease
Disease Progression
Humans
Import
Kinase
Nfat4
Nuclear
Protein Kinases - chemistry
Protein Kinases - metabolism
Protein Kinases - physiology
Protein Transport - physiology
Proto-Oncogene Proteins - metabolism
Rhythm
Signal Transduction - physiology
Signaling
Wnt
Wnt Proteins
Zebrafish Proteins
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Description
Summary:The casein kinase I (CKI) family of protein kinases is a group of highly related, ubiquitously expressed serine/threonine kinases found in all eukaryotic organisms from protozoa to man. Recent advances in diverse fields, including developmental biology and chronobiology, have elucidated roles for CKI in regulating critical processes such as Wnt signaling, circadian rhythm, nuclear import, and Alzheimer's disease progression.
ISSN:1521-6543
1521-6551
DOI:10.1080/15216540117461