Long-term results of duodenectomy with highly selective vagotomy in the treatment of complicated duodenal ulcers

• Published in: The American journal of surgery 2001-04, Vol.181 (4), p.372-376
• Main Authors: Chang, Tzu-Ming, Chan, De-Chuan, Liu, Yao-Chi, Tsou, Shung-Sheng, Chen, Tzu-Hung
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Complete circular duodenectomy; Complications; Diarrhea; Dissection; Dumping; Duodenal Ulcer - complications; Duodenal Ulcer - surgery; Duodenum - surgery; Endoscopy; Female; Follow-Up Studies; Gastric Outlet Obstruction - etiology; Gastric Outlet Obstruction - surgery; Gastroenterology. Liver. Pancreas. Abdomen; Highly selective vagotomy; Humans; Male; Medical sciences; Middle Aged; Mortality; Nutrition; Other diseases. Semiology; Partial duodenectomy; Patients; Peptic Ulcer Perforation - surgery; Peptic ulcers; Pyloric Antrum - surgery; Retrospective Studies; Small intestine; Stomach, duodenum, intestine, rectum, anus; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surgeons; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Sutures; Truncal vagotomy and antrectomy; Ulcers; Vagotomy; Vagotomy, Proximal Gastric; Vagotomy, Truncal; Vomiting; Weight; Weight Gain; Weight loss
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/S0002-9610(01)00580-3

Background: Highly selective vagotomy and complete circular or partial duodenectomy have been applied to complicated duodenal ulcer for many years. These procedures seem to provide better clinical results than truncal vagotomy and antrectomy. Methods: A retrospective analysis was conducted of 120 patients with complicated duodenal ulcer who underwent surgical treatment between 1986 and 1999. Patients with obstruction were treated with either circular complete (17) or partial duodenectomy (3) combined with highly selective vagotomy or truncal vagotomy and antrectomy (37). Those with perforation were treated primarily with highly selective vagotomy and partial duodenectomy, highly selective vagotomy alone, or truncal vagotomy and pyloroplasty. Every patient was followed up either by a clinic visit (75%) or questionnaire to determine the presence of ulcer pain, dumping, diarrhea, vomiting, weight loss, and Visick grade. Results: Long-term follow-up of patients treated with duodenectomy and highly selective vagotomy for obstruction showed that 94% had sustained weight gain whereas more than half of those treated with truncal vagotomy and antrectomy had weight loss. In patients with perforation, duodenectomy and highly selective vagotomy offered no advantage over highly selective vagotomy alone. Conclusions: Highly selective vagotomy and complete circular or partial duodenectomy provide fewer sequelae and better weight gain long term than truncal vagotomy and antrectomy for patients with obstructing duodenal ulcers.