Dynamics of DNA methylation pattern

Methylation patterns are the result of de novo methylation, demethylation, and the maintenance of existing methylation. Although the existence and identity of an active demethylase remain in doubt, recent evidence suggests that protein binding can specify sites of demethylation through a replication...

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Bibliographic Details
Published in:Current Opinion in Genetics & Development 2000-04, Vol.10 (2), p.224-228
Main Author: Hsieh, Chih-Lin
Format: Article
Language:English
Subjects:
Animals
DNA (Cytosine-5-)-Methyltransferase 1
DNA (Cytosine-5-)-Methyltransferases - genetics
DNA (Cytosine-5-)-Methyltransferases - metabolism
DNA Methylation
DNA methyltransferase
DNA Methyltransferase 3A
DNA Methyltransferase 3B
Drosophila
Drosophila Proteins
episomes
Humans
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Summary:Methylation patterns are the result of de novo methylation, demethylation, and the maintenance of existing methylation. Although the existence and identity of an active demethylase remain in doubt, recent evidence suggests that protein binding can specify sites of demethylation through a replication-dependent pathway. By using a stable episomal system in human cells, plus the Drosophila system, and mouse embryonic stem cells, we are beginning to understand the function and targets of de novo methyltransferases in murine and human cells.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00064-2