Evidence on major gene control of cortical index in pedigree data from Middle Dalmatia, Croatia

It was recently reported that the inheritance of the metacarpal cortical index (CI) in the Chuvashian population can be described in terms of a major gene (MG) model. By applying transmission probability tests, the hypothesis was accepted that not only baseline level of CI but also its sex‐specific...

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Bibliographic Details
Published in:American journal of human biology 2001-05, Vol.13 (3), p.398-408
Main Authors: Ginsburg, Emil, Škarić-Jurić, Tatjana, Kobyliansky, Eugene, Malkin, Ida, Rudan, Pavao
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Age of Onset
Aged
Aged, 80 and over
Bone Density - genetics
Chromosome Segregation - genetics
Croatia - epidemiology
Effect Modifier, Epidemiologic
Female
Gene Frequency - genetics
Genetic Variation - genetics
Genotype
Humans
Male
Metacarpus - anatomy & histology
Middle Aged
Models, Genetic
Multifactorial Inheritance - genetics
Osteoporosis - epidemiology
Osteoporosis - genetics
Pedigree
Sex Characteristics
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Summary:It was recently reported that the inheritance of the metacarpal cortical index (CI) in the Chuvashian population can be described in terms of a major gene (MG) model. By applying transmission probability tests, the hypothesis was accepted that not only baseline level of CI but also its sex‐specific dependence on age were under control of the same putative large‐effect gene. Using a pedigree sample from the population of the islands of Middle Dalmatia, Croatia (847 observed individuals in 278 pedigrees), data are presented to support the above findings. The following hypotheses were accepted: (i) inheritance of baseline CI in the Croatian population can be attributed to the effect of a MG responsible for about 42% of the variation; (ii) the same MG takes part in the control of the dependence of CI on age, particularly the age at onset of involutive bone changes (inflection point), and of the rate of decrease in CI with age (slope coefficient). Issues related to the assortative mating effect on CI and the determination of the most parsimonious model are discussed. Am. J. Hum. Biol. 13:398–408, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:1042-0533
1520-6300
DOI:10.1002/ajhb.1064