MRI investigation of hydration and heterogeneous degradation of aliphatic polyesters derived from lactic and glycolic acids: a controlled drug delivery device

Magnetic Resonance Imaging experiments have been used to investigate the degradation of drug-loaded poly(glycolic lactic acid) (PGLA) 50:50 cylinders. Spatial variation in the rate of degradation throughout the polymer cross-section has been observed non-invasively using quantitative imaging of pene...

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Bibliographic Details
Published in:Magnetic resonance imaging 2001-04, Vol.19 (3), p.521-523
Main Authors: Djemai, A., Gladden, L.F., Booth, J., Kittlety, R.S., Gellert, P.R.
Format: Article
Language:English
Subjects:
Autocatalytic reaction
Biological and medical sciences
Catalysis
Drug Carriers - chemistry
Drug Delivery Systems
Drug Stability
Glycolates - chemistry
Investigative techniques, diagnostic techniques (general aspects)
Lactic Acid - chemistry
Magnetic Resonance Imaging - methods
Medical sciences
Miscellaneous. Technology
MRI
PGLA
Polyesters - chemistry
Polymer degradation
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Water - chemistry
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Summary:Magnetic Resonance Imaging experiments have been used to investigate the degradation of drug-loaded poly(glycolic lactic acid) (PGLA) 50:50 cylinders. Spatial variation in the rate of degradation throughout the polymer cross-section has been observed non-invasively using quantitative imaging of penetrant concentration, T 2 and self-diffusion coefficient. This spatial variation in the rate of degradation was attributed to the quicker degradation in the inner region of the sample due to autocatalysis by carboxyl end groups generated upon ester bond cleavage.
ISSN:0730-725X
1873-5894
DOI:10.1016/S0730-725X(01)00283-1