The role of scavenger receptors in the innate immune system

Akey aspect of the innate immune system is the ability to discriminate between self and infectious nonself. This is achieved through pattern recognition receptors which directly recognise molecular epitopes expressed by microbes. Scavenger receptors (SRs) have been studied primarily due to their abi...

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Bibliographic Details
Published in:Microbes and infection 2000-03, Vol.2 (3), p.305-311
Main Authors: Gough, Peter J., Gordon, Siamon
Format: Article
Language:English
Subjects:
Animals
Humans
Immunity - immunology
innate immunity
Ligands
Lipoproteins - immunology
macrophage
Membrane Proteins
Mice
Mice, Knockout
Phagocytosis
Receptors, Immunologic - classification
Receptors, Immunologic - immunology
Receptors, Lipoprotein
Receptors, Scavenger
scavenger receptor
scavenger receptors
Scavenger Receptors, Class B
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Summary:Akey aspect of the innate immune system is the ability to discriminate between self and infectious nonself. This is achieved through pattern recognition receptors which directly recognise molecular epitopes expressed by microbes. Scavenger receptors (SRs) have been studied primarily due to their ability to bind and internalise modified lipoproteins, suggesting an important role in foam cell formation and the pathogenesis of atherosclerosis. However, the ability of some SRs to function as pattern recognition receptors through their binding of a wide variety of pathogens indicates a potential role in host defence. This review will detail our current understanding of the function of SRs in innate immunity, and in the initiation of aquired immune responses.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(00)00297-5