Actions and interactions of the IGF system in Alzheimer’s disease: review and hypotheses

Insulin-like growth factors (IGF) are pleiotrophic polypeptides affecting all aspects of growth and development. The IGF system, including ligands, receptors, binding proteins and proteases is also involved in pathophysiological conditions, such as cancer and degenerative conditions. In this review,...

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Bibliographic Details
Published in:Growth hormone & IGF research 2000-02, Vol.10 (1), p.1-13
Main Authors: Lackey, Brett R., Gray, Sandra L., Henricks, Donald M.
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Apoptosis
Caspases - metabolism
Humans
Immunity, Innate
Insulin - metabolism
Key words: IGF, Alzheimer’s, cytokine, apoptosis, diabetes
Mitochondria - metabolism
Neurons - metabolism
Neurons - physiology
Proto-Oncogene Proteins c-bcl-2 - metabolism
Somatomedins - metabolism
Somatomedins - physiology
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Summary:Insulin-like growth factors (IGF) are pleiotrophic polypeptides affecting all aspects of growth and development. The IGF system, including ligands, receptors, binding proteins and proteases is also involved in pathophysiological conditions, such as cancer and degenerative conditions. In this review, the actions and interactions of the IGF system as it relates to Alzheimer’s disease will be investigated.
ISSN:1096-6374
1532-2238
DOI:10.1054/ghir.1999.0129