Succession of events in desquamation of superficial urothelial cells as a response to stress induced by prolonged constant illumination

The effect of moderate stress induced by prolonged illumination was analysed on urothelial cells of female mouse urinary bladders at ultrastructural and cytochemical levels. This study demonstrates that the urothelium responds to moderate stress with desquamation which involves two subsequent steps....

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Bibliographic Details
Published in:Tissue & cell 2001-06, Vol.33 (3), p.280-285
Main Authors: Veranič, P., Jezernik, K.
Format: Article
Language:English
Subjects:
Animals
Desmosomes - pathology
Desmosomes - ultrastructure
Female
Lighting
Lysosomes - enzymology
Mice
Mice, Inbred Strains
Microscopy, Electron
Nucleotidases - analysis
Stress, Physiological - pathology
Tight Junctions - pathology
Tight Junctions - ultrastructure
urinary bladder, stress, desquamation, tight junction, desmosomes
Urothelium - pathology
Urothelium - ultrastructure
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Summary:The effect of moderate stress induced by prolonged illumination was analysed on urothelial cells of female mouse urinary bladders at ultrastructural and cytochemical levels. This study demonstrates that the urothelium responds to moderate stress with desquamation which involves two subsequent steps. The first step includes a local detachment of tight junctions and consequently the loss of the permeability barrier leading to expanded intercellular spaces among urothelial cells. During the second step, the disjunction of desmosomes accompanied by exocytosis of lysosomal enzymes (NADPase) in the intercellular space results in exfoliation of superficial cells. It is evident thatmoderate stress elicits an enhanced desquamation of only superficial cells by a subsequent dysfunction of first tight junctions and after that adherens-type junctions. A rapid restoration of the newtight junctions prevents a long-term malfunction of the blood–urine barrier.
ISSN:0040-8166
1532-3072
DOI:10.1054/tice.2001.0175