Lactate-stress testing in 54 patients with mitochondriopathy

Since there are only few data available about the lactate stress test in a group of patients with mitochondrial myopathy, we investigated the sensitivity of this test in a larger cohort of such patients. Serum lactate was determined before, during and after a 15 minute, constant 30 W workload on a b...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2000, Vol.250 (1), p.36-39
Main Authors: Finsterer, J, Eichberger, H, Jarius, C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Associations
Cohort Studies
Electromyography
Ergometry - statistics & numerical data
Female
Humans
Lactic Acid - blood
Male
Middle Aged
Mitochondria, Muscle - metabolism
Mitochondria, Muscle - pathology
Mitochondrial Myopathies - blood
Mitochondrial Myopathies - diagnosis
Mitochondrial Myopathies - metabolism
Muscle Contraction - physiology
Muscle Fibers, Skeletal - pathology
Muscles - metabolism
Muscles - pathology
Muscles - physiology
Muscular dystrophy
Oxidative Stress
Physical Exertion - physiology
Regulation of financial institutions
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Summary:Since there are only few data available about the lactate stress test in a group of patients with mitochondrial myopathy, we investigated the sensitivity of this test in a larger cohort of such patients. Serum lactate was determined before, during and after a 15 minute, constant 30 W workload on a bicycle ergometer in 47 controls, aged 15 to 72 years and 54 patients with mitochondrial myopathy, aged 15 to 74 years. Lactate's upper reference limits at rest, 5, 10, 15 minutes after starting, and 15 minutes after finishing the exercise were 2.0, 2.1, 2.1, 2.1 and 1.8 mmol/l respectively. The sensitivity of the lactate-stress test was 69%. The lactate-stress test complements electrophysiological and bioptical findings and proved to be helpful in diagnosing mitochondrial myopathy.
ISSN:0940-1334
1433-8491
DOI:10.1007/PL00007537