Type-specific Sorting of G Protein-coupled Receptors after Endocytosis

The β2-adrenergic receptor (B2AR) and δ-opioid receptor (DOR) are structurally distinct G protein-coupled receptors (GPCRs) that undergo rapid, agonist-induced internalization by clathrin-coated pits. We have observed that these receptors differ substantially in their membrane trafficking after endo...

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Bibliographic Details
Published in:The Journal of biological chemistry 2000-04, Vol.275 (15), p.11130-11140
Main Authors: Tsao, Patricia I., von Zastrow, Mark
Format: Article
Language:English
Subjects:
Cell Membrane - metabolism
Cells, Cultured
Endocytosis
Enkephalin, Leucine-2-Alanine - pharmacology
Humans
Isoproterenol - pharmacology
Microscopy, Fluorescence
Receptors, Adrenergic, beta-2 - analysis
Receptors, Adrenergic, beta-2 - metabolism
Receptors, Opioid, delta - analysis
Receptors, Opioid, delta - metabolism
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Summary:The β2-adrenergic receptor (B2AR) and δ-opioid receptor (DOR) are structurally distinct G protein-coupled receptors (GPCRs) that undergo rapid, agonist-induced internalization by clathrin-coated pits. We have observed that these receptors differ substantially in their membrane trafficking after endocytosis. B2AR expressed in stably transfected HEK293 cells exhibits negligible (
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.275.15.11130