Comparison of cardiac troponin T versus creatine kinase-mb for risk stratification in a chest pain evaluation unit

We evaluated cardiac troponin T (cTnT) and creatine kinase-MB (CK-MB) for risk stratification of chest pain unit (CPU) patients. We studied 383 consecutive patients with chest pain assigned to our CPU by emergency department physicians. At baseline all had normal or nondiagnostic electrocardiograms,...

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Bibliographic Details
Published in:The American journal of cardiology 2000-04, Vol.85 (7), p.801-805
Main Authors: Newby, L.Kristin, Kaplan, Andrew L, Granger, Bradi B, Sedor, Frank, Califf, Robert M, Ohman, E.Magnus
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers - blood
Cardiology
Cardiology. Vascular system
Chest Pain - blood
Chest Pain - diagnosis
Coronary Care Units
Coronary heart disease
Creatine Kinase - blood
Diagnosis, Differential
Electrocardiography
Enzymes
Female
Heart
Humans
Isoenzymes
Male
Medical sciences
Middle Aged
Myocardium - metabolism
Pain
Prognosis
Retrospective Studies
Risk Assessment
Troponin T - blood
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Summary:We evaluated cardiac troponin T (cTnT) and creatine kinase-MB (CK-MB) for risk stratification of chest pain unit (CPU) patients. We studied 383 consecutive patients with chest pain assigned to our CPU by emergency department physicians. At baseline all had normal or nondiagnostic electrocardiograms, no high-risk clinical features, and negative CK/CK-MB. CK-MB and electrocardiograms were taken at 0, 4, 8, and 12 hours and cTnT at 0, 4, and 8 hours. Eight patients (2.1%) were CK-MB positive and 39 (10.2%) were cTnT positive, including all but 1 CK-MB-positive patient. All marker-positive patients were detected by 8 hours. Seven cTnT-positive patients and 1 cTnT-negative patient had myocardial infarction (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00870-X