THE INHIBITORY EFFECTS OF TERIKALANT ON THE CONTRACTILE ACTIVITY OF GALANIN IN ISOLATED RAT FUNDUS STRIPS

The maximal responses (Emaxs) of isolated rat gastric fundus strips to 300 nm porcine galanin (Gal) were decreased in a concentration-dependent manner by terikalant (RP 62719). EC50of the agent equalled 4.39 μm (2.35–8.22). On the contrary the action of 30 n m of carbachol were not affected by the m...

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Bibliographic Details
Published in:Pharmacological research 2000-05, Vol.41 (5), p.585-587
Main Authors: KOROLKIEWICZ, R.P., KONSTAŃSKI, Z., REKOWSKI, P., RUCZYŃSKI, J., SZYK, A., SZCZEPAŃSKA, R., PETRUSEWICZ, J.
Format: Article
Language:English
Subjects:
Animals
Chromans - pharmacology
Dose-Response Relationship, Drug
Female
Galanin - antagonists & inhibitors
galanin, gastric fundus, terikalant, rat
Gastric Fundus - drug effects
Gastric Fundus - physiology
In Vitro Techniques
Male
Muscle Contraction - drug effects
Piperidines - pharmacology
Potassium Channels - drug effects
Rats
Rats, Wistar
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Summary:The maximal responses (Emaxs) of isolated rat gastric fundus strips to 300 nm porcine galanin (Gal) were decreased in a concentration-dependent manner by terikalant (RP 62719). EC50of the agent equalled 4.39 μm (2.35–8.22). On the contrary the action of 30 n m of carbachol were not affected by the modulator in concentrations up to 30 μm. It is concluded that potassium currents may contribute to the modulation of Gal myotropic activity in the gut.
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1999.0621