Neuropsychological Outcome Following Unilateral Stereotactic Pallidotomy in Intractable Parkinson's Disease

Neuropsychological functioning was examined at baseline and 2- to 3-month follow-up in 40 subjects with advanced Parkinson's disease (PD) who underwent unilateral posteroventral pallidotomy. Most subjects demonstrated improved verbal learning, visual memory, confrontation naming, and figural fl...

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Bibliographic Details
Published in:Brain and cognition 2000-04, Vol.42 (3), p.364-378
Main Authors: Lacritz, Laura H., Cullum, C.Munro, Frol, Alan B., Dewey, Richard B., Giller, Cole A.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Female
Follow-Up Studies
Globus Pallidus - surgery
Humans
Male
Medical sciences
Middle Aged
Neuropsychological Tests
Neurosurgical Procedures - methods
Organic mental disorders. Neuropsychology
Parkinson Disease - psychology
Parkinson Disease - surgery
Postoperative Complications
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Severity of Illness Index
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Summary:Neuropsychological functioning was examined at baseline and 2- to 3-month follow-up in 40 subjects with advanced Parkinson's disease (PD) who underwent unilateral posteroventral pallidotomy. Most subjects demonstrated improved verbal learning, visual memory, confrontation naming, and figural fluency at follow-up. Right pallidotomy was associated with decreased cognitive flexibility and increased verbal fluency, whereas Left pallidotomy uniquely resulted in a decline in verbal fluency. Significant motor improvement was demonstrated in both groups. Pallidotomy appears to be an effective treatment for advanced PD, providing a significant improvement in motor functioning, while resulting in few deleterious neurocognitive changes in most cases.
ISSN:0278-2626
1090-2147
DOI:10.1006/brcg.1999.1110