Hippocampus formation: an intriguing collaboration

Recent genetic studies have shown that the signalling factor Wnt3a is required for formation of the hippocampus; the developmental consequences of Wnt signalling in the hippocampus are mediated by multiple HMG-box transcription factors, with LEF-1 being required just for formation of the dentate gyr...

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Bibliographic Details
Published in:Current biology 2000-04, Vol.10 (7), p.R279-R281
Main Author: Roelink, H
Format: Article
Language:English
Subjects:
Animals
DNA-Binding Proteins - genetics
Embryonic Induction
High Mobility Group Proteins - genetics
Hippocampus - embryology
LEF-1 protein
Lymphoid Enhancer-Binding Factor 1
Mice
Mice, Mutant Strains
Proteins - genetics
Transcription Factors - genetics
Wnt Proteins
Wnt-3a protein
Wnt3 Protein
Wnt3A Protein
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Summary:Recent genetic studies have shown that the signalling factor Wnt3a is required for formation of the hippocampus; the developmental consequences of Wnt signalling in the hippocampus are mediated by multiple HMG-box transcription factors, with LEF-1 being required just for formation of the dentate gyrus.
ISSN:0960-9822
DOI:10.1016/s0960-9822(00)00407-3