Massive solitary metastasis of hepatocellular carcinoma in the ovary two years after liver transplantation

Case report of a 47-year-old woman with a mass in the lower abdomen, was referred to us by the surgeon, two years after orthotopic liver transplantation for hepatocellular carcinoma (HCC). Serum alpha-fetoprotein (AFP), which was elevated at the time of initial diagnosis, was in the normal range. Fr...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2000-05, Vol.90 (1), p.109-111
Main Authors: de Groot, Marlies E, Dukel, Lenno, Chadha-Ajwani, Savi, Metselaar, Herold J, Tilanus, Hugo W, Huikeshoven, Frans J
Format: Article
Language:English
Subjects:
Abdominal mass
alpha-Fetoproteins - analysis
Alphafetoproteine
Biological and medical sciences
Biomarkers, Tumor - blood
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - secondary
Female
Female genital diseases
Gastroenterology. Liver. Pancreas. Abdomen
Gynecology. Andrology. Obstetrics
Hepatocellular carcinoma
Humans
Laparotomy
Liver Neoplasms - pathology
Liver Transplantation
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Middle Aged
Ovarian metastasis
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - secondary
Tumors
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Summary:Case report of a 47-year-old woman with a mass in the lower abdomen, was referred to us by the surgeon, two years after orthotopic liver transplantation for hepatocellular carcinoma (HCC). Serum alpha-fetoprotein (AFP), which was elevated at the time of initial diagnosis, was in the normal range. Frozen section examination during exploratory laparotomy showed appearances consistent with metastatic HCC in the ovary. This was confirmed at the final pathological examination. Definitive pathological conclusions were based on the findings of tumor cells arranged in trabecular and papillary aggregates, and the presence of bile-pigment, along with the patients history. This is the sixth case of metastatic HCC in the ovary being described in literature and the first case in which this metastasis was not accompanied by elevated AFP.
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(99)00212-2