Paraoxonase producing PON1 gene M/L55 polymorphism is related to autopsy-verified artery-wall atherosclerosis

Paraoxonase (PON) is an antioxidative enzyme, which eliminates lipid peroxides. PON has two common polymorphisms (M/L55 and R/Q192) that influence PON concentration and activity. We studied whether the M/L55 or R/Q192 genotype relates with the severity of atherosclerosis of the abdominal aorta, and...

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Bibliographic Details
Published in:Atherosclerosis 2001-08, Vol.157 (2), p.301-307
Main Authors: Malin, Riikka, Järvinen, Otso, Sisto, Tero, Koivula, Timo, Lehtimäki, Terho
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Aorta, Abdominal - pathology
Arteries
Arteriosclerosis - genetics
Arteriosclerosis - metabolism
Arteriosclerosis - pathology
Aryldialkylphosphatase
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Autopsy study
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Constriction, Pathologic
Esterases - genetics
Esterases - metabolism
Female
Genotype
Heterozygote
Homozygote
Humans
Iliac Artery - pathology
Male
Medical sciences
Mesenteric Arteries - pathology
Middle Aged
Paraoxonase genotype
Polymorphism, Genetic
Risk factors
Severity of Illness Index
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Summary:Paraoxonase (PON) is an antioxidative enzyme, which eliminates lipid peroxides. PON has two common polymorphisms (M/L55 and R/Q192) that influence PON concentration and activity. We studied whether the M/L55 or R/Q192 genotype relates with the severity of atherosclerosis of the abdominal aorta, and the mesenteric and common iliac arteries in 123 consecutive autopsy cases (90 males and 33 females, aged 18–93 years). The severity of atherosclerosis in the arteries was evaluated, and the percentage of stenosis was measured. The intimal thickness in the internal elastic lamina (IEL) of the coeliac (CA), superior mesenteric (SMA) and inferior mesenteric (IMA) arteries were measured by light-microscopy. The LL homozygous men had more atherosclerotic plaques and complicated lesions in the common iliac arteries (56.8%) than the M allele carriers (28.3%, P=0.007). In logistic regression analysis, age ( P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(00)00728-0