Excess coronary heart disease in Familial Combined Hyperlipidemia, in relation to genetic factors and central obesity

• Published in: Atherosclerosis 2001-08, Vol.157 (2), p.481-489
• Main Authors: Voors-Pette, Christine, de Bruin, Tjerk W.A.
• Format: Article
• Language: English
• Subjects: Adult; Alleles; Apolipoprotein A-I - genetics; Apolipoprotein C-III; Apolipoproteins A - genetics; Apolipoproteins C - genetics; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Body Constitution; Cardiology. Vascular system; Coronary disease; Coronary Disease - complications; Coronary Disease - epidemiology; Female; Gene Frequency; Genetics; Humans; Hyperlipidemia, Familial Combined - complications; Hyperlipidemia, Familial Combined - genetics; Lipids; Male; Medical sciences; Middle Aged; Multigene Family; Obesity - complications; Polymorphism, Genetic; Prevalence; Risk Factors
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/S0021-9150(00)00752-8

Aim: To determine the prevalence of non-fatal coronary artery disease (CAD) in kindred with Familial Combined Hyperlipidemia (FCHL) in relation to various cardiovascular risk factors and DNA variation in the apo AI-CIII-AIV gene cluster. Methods and Results: Data were collected from 18 Dutch FCHL probands, 202 living first and second degree relatives, and 175 spouses. Probands and first degree relatives showed dyslipidemia, increased plasma insulin and glucose concentrations, higher waist–hip ratio (WHR), and blood pressure, than spouses. The frequency of the minor alleles M2 and S2 was increased in probands and first degree relatives. The Odds Ratio for CAD was 5.3 in male FCHL relatives ( P=0.005), and 5.1 in all FCHL relatives ( P=0.001). First and second degree relatives had a markedly reduced CAD-free life-span (log rank vs. spouses: P