Platelet 3H Ketanserin Binding in Migraine

Platelet 3H ketanserin binding was studied in 33 patients of migraine and 30 healthy controls. The binding characteristics: equilibrium dissociation constant (Kd) and maximal number of binding sites (Bmax) determined by Scatchard analysis revealed a significant decrease in Kd and no change in Bmax i...

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Bibliographic Details
Published in:Cephalalgia 2001-06, Vol.21 (5), p.567-572
Main Authors: Shukla, R, Khanna, VK, Pradeep, S, Husain, M, Tandon, R, Nag, D, Dikshit, M, Srimal, RC, Seth, PK
Format: Article
Language:English
Subjects:
3H ketanserin binding
5‐HT2 receptors
Adult
Blood Platelets - metabolism
Female
Humans
Ketanserin - metabolism
Kinetics
Male
migraine
Migraine Disorders - blood
Platelets
Protein Binding
Receptors, Serotonin - blood
Receptors, Serotonin - physiology
serotonin
Serotonin - physiology
Serotonin Antagonists - metabolism
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Summary:Platelet 3H ketanserin binding was studied in 33 patients of migraine and 30 healthy controls. The binding characteristics: equilibrium dissociation constant (Kd) and maximal number of binding sites (Bmax) determined by Scatchard analysis revealed a significant decrease in Kd and no change in Bmax in migraine cases. No correlation was observed between the Kd and Bmax with the clinical features of migraine. The findings of the present study show that there is a decreased affinity of platelet 5-HT2 receptors in migraine.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.2001.00195.x