Synthesis of 19-[(2-Azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue

New photoaffinity probes based on C-19 position of leukotriene A4 has been synthesized from 19-hydroxy-LTA4 methyl ester. Enzymatic conversion into the LTC4 analogue yielded a potential tool for the study of cys-LT2 receptors.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2000-04, Vol.10 (7), p.665-668
Main Authors: VIDAL, A, DURAND, T, VIDAL, J.-P, ROSSI, A. J.-C, RAVASI, S, ZARINI, S, SALA, A
Format: Article
Language:English
Subjects:
Aliphatic compounds
Blood Platelets - enzymology
Blood Platelets - metabolism
Chemistry
Exact sciences and technology
Glutathione Transferase - metabolism
Humans
Leukotriene A4 - analogs & derivatives
Leukotriene A4 - chemical synthesis
Leukotriene A4 - metabolism
Leukotriene C4 - analogs & derivatives
Leukotriene C4 - chemical synthesis
Leukotriene C4 - chemistry
Organic chemistry
Organotin Compounds - chemical synthesis
Organotin Compounds - metabolism
Preparations and properties
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Description
Summary:New photoaffinity probes based on C-19 position of leukotriene A4 has been synthesized from 19-hydroxy-LTA4 methyl ester. Enzymatic conversion into the LTC4 analogue yielded a potential tool for the study of cys-LT2 receptors.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00076-7