Loading…
Evaluation of the Abbott CELL-DYN 4000 hematology analyzer
A new generation hematology analyzer, Abbott CELL-DYN 4000 (CD 4000), capable of providing 26 parameters, including fully automated reticulocyte, nucleated RBC, blast, band, and immature granulocyte, and variant lymphocyte counts, was evaluated by using the National Committee for Clinical Laboratory...
Saved in:
Published in: | American journal of clinical pathology 2000-04, Vol.113 (4), p.497-505 |
---|---|
Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c307t-dc80e7704093cac1e2410f9a2b72785c627e8131cae0da477b70a20d2c9b5fde3 |
---|---|
cites | cdi_FETCH-LOGICAL-c307t-dc80e7704093cac1e2410f9a2b72785c627e8131cae0da477b70a20d2c9b5fde3 |
container_end_page | 505 |
container_issue | 4 |
container_start_page | 497 |
container_title | American journal of clinical pathology |
container_volume | 113 |
creator | GRIMALDI, E SCOPACASA, F |
description | A new generation hematology analyzer, Abbott CELL-DYN 4000 (CD 4000), capable of providing 26 parameters, including fully automated reticulocyte, nucleated RBC, blast, band, and immature granulocyte, and variant lymphocyte counts, was evaluated by using the National Committee for Clinical Laboratory Standards H20-A protocol and compared with the Bayer-Technicon H-2 analyzer, which is used routinely in our laboratory. A lipid interference experiment and a sample aging study also were performed. Linearity, carryover, and precision were within the limits established by the manufacturer, and satisfactory agreement was found with the H-2 analyzer. The evaluation of leukocyte differential counts indicated an excellent correlation with the manual reference method for neutrophils and lymphocytes, a good correlation for monocytes and eosinophils, and a poor correlation for basophils in samples with low counts; for basophil counts of 2% or higher, we found an improvement of the correlation coefficient. In the lipid interference experiment, only hemoglobin determination was influenced significantly on the CD 4000, but by using a new Abbott hemoglobin reagent, the interference was eliminated. The CBC and differential counts were stable and reportable up to at least 24 hours. Intrasample viability information on leukocytes provided a quality check on each individual specimen. |
doi_str_mv | 10.1309/L7LC-6KKJ-12G2-196W |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71039482</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71039482</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-dc80e7704093cac1e2410f9a2b72785c627e8131cae0da477b70a20d2c9b5fde3</originalsourceid><addsrcrecordid>eNpNkM1Kw0AURgdRbK0-gSBZiLvROz_NJO4k1qoNulHE1XAzmdhI0qmZRKhPb0ILuvo25zuLQ8gpg0smIL5KVZrQcLF4pIzPOWVx-LZHxiyWgirF-T4ZAwCnMVNiRI68_wRgPAJ5SEYMVMjkFMbkevaNVYdt6VaBK4J2aYObLHNtGySzNKW370-B7DXB0tbYusp9bAJcYbX5sc0xOSiw8vZktxPyejd7Se5p-jx_SG5SagSoluYmAqsUSIiFQcMslwyKGHmmuIqmJuTKRkwwgxZylEplCpBDzk2cTYvcigm52HrXjfvqrG91XXpjqwpX1nVeKwYilhHvQbEFTeO8b2yh101ZY7PRDPSQTA_J9JBMD8n0kKx_ne30XVbb_N9n26gHzncAeoNV0eDKlP6PE0xFHMQvPhxyGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71039482</pqid></control><display><type>article</type><title>Evaluation of the Abbott CELL-DYN 4000 hematology analyzer</title><source>Oxford Journals Online</source><creator>GRIMALDI, E ; SCOPACASA, F</creator><creatorcontrib>GRIMALDI, E ; SCOPACASA, F</creatorcontrib><description>A new generation hematology analyzer, Abbott CELL-DYN 4000 (CD 4000), capable of providing 26 parameters, including fully automated reticulocyte, nucleated RBC, blast, band, and immature granulocyte, and variant lymphocyte counts, was evaluated by using the National Committee for Clinical Laboratory Standards H20-A protocol and compared with the Bayer-Technicon H-2 analyzer, which is used routinely in our laboratory. A lipid interference experiment and a sample aging study also were performed. Linearity, carryover, and precision were within the limits established by the manufacturer, and satisfactory agreement was found with the H-2 analyzer. The evaluation of leukocyte differential counts indicated an excellent correlation with the manual reference method for neutrophils and lymphocytes, a good correlation for monocytes and eosinophils, and a poor correlation for basophils in samples with low counts; for basophil counts of 2% or higher, we found an improvement of the correlation coefficient. In the lipid interference experiment, only hemoglobin determination was influenced significantly on the CD 4000, but by using a new Abbott hemoglobin reagent, the interference was eliminated. The CBC and differential counts were stable and reportable up to at least 24 hours. Intrasample viability information on leukocytes provided a quality check on each individual specimen.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/L7LC-6KKJ-12G2-196W</identifier><identifier>PMID: 10761450</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Autoanalysis ; Biological and medical sciences ; Blood Cell Count - instrumentation ; Evaluation Studies as Topic ; Hematology ; Hematology - instrumentation ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lipids - blood ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Reproducibility of Results ; Specimen Handling</subject><ispartof>American journal of clinical pathology, 2000-04, Vol.113 (4), p.497-505</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-dc80e7704093cac1e2410f9a2b72785c627e8131cae0da477b70a20d2c9b5fde3</citedby><cites>FETCH-LOGICAL-c307t-dc80e7704093cac1e2410f9a2b72785c627e8131cae0da477b70a20d2c9b5fde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1317820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10761450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GRIMALDI, E</creatorcontrib><creatorcontrib>SCOPACASA, F</creatorcontrib><title>Evaluation of the Abbott CELL-DYN 4000 hematology analyzer</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>A new generation hematology analyzer, Abbott CELL-DYN 4000 (CD 4000), capable of providing 26 parameters, including fully automated reticulocyte, nucleated RBC, blast, band, and immature granulocyte, and variant lymphocyte counts, was evaluated by using the National Committee for Clinical Laboratory Standards H20-A protocol and compared with the Bayer-Technicon H-2 analyzer, which is used routinely in our laboratory. A lipid interference experiment and a sample aging study also were performed. Linearity, carryover, and precision were within the limits established by the manufacturer, and satisfactory agreement was found with the H-2 analyzer. The evaluation of leukocyte differential counts indicated an excellent correlation with the manual reference method for neutrophils and lymphocytes, a good correlation for monocytes and eosinophils, and a poor correlation for basophils in samples with low counts; for basophil counts of 2% or higher, we found an improvement of the correlation coefficient. In the lipid interference experiment, only hemoglobin determination was influenced significantly on the CD 4000, but by using a new Abbott hemoglobin reagent, the interference was eliminated. The CBC and differential counts were stable and reportable up to at least 24 hours. Intrasample viability information on leukocytes provided a quality check on each individual specimen.</description><subject>Autoanalysis</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count - instrumentation</subject><subject>Evaluation Studies as Topic</subject><subject>Hematology</subject><subject>Hematology - instrumentation</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lipids - blood</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Reproducibility of Results</subject><subject>Specimen Handling</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpNkM1Kw0AURgdRbK0-gSBZiLvROz_NJO4k1qoNulHE1XAzmdhI0qmZRKhPb0ILuvo25zuLQ8gpg0smIL5KVZrQcLF4pIzPOWVx-LZHxiyWgirF-T4ZAwCnMVNiRI68_wRgPAJ5SEYMVMjkFMbkevaNVYdt6VaBK4J2aYObLHNtGySzNKW370-B7DXB0tbYusp9bAJcYbX5sc0xOSiw8vZktxPyejd7Se5p-jx_SG5SagSoluYmAqsUSIiFQcMslwyKGHmmuIqmJuTKRkwwgxZylEplCpBDzk2cTYvcigm52HrXjfvqrG91XXpjqwpX1nVeKwYilhHvQbEFTeO8b2yh101ZY7PRDPSQTA_J9JBMD8n0kKx_ne30XVbb_N9n26gHzncAeoNV0eDKlP6PE0xFHMQvPhxyGA</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>GRIMALDI, E</creator><creator>SCOPACASA, F</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Evaluation of the Abbott CELL-DYN 4000 hematology analyzer</title><author>GRIMALDI, E ; SCOPACASA, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-dc80e7704093cac1e2410f9a2b72785c627e8131cae0da477b70a20d2c9b5fde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Autoanalysis</topic><topic>Biological and medical sciences</topic><topic>Blood Cell Count - instrumentation</topic><topic>Evaluation Studies as Topic</topic><topic>Hematology</topic><topic>Hematology - instrumentation</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lipids - blood</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Reproducibility of Results</topic><topic>Specimen Handling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GRIMALDI, E</creatorcontrib><creatorcontrib>SCOPACASA, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GRIMALDI, E</au><au>SCOPACASA, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Abbott CELL-DYN 4000 hematology analyzer</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>113</volume><issue>4</issue><spage>497</spage><epage>505</epage><pages>497-505</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>A new generation hematology analyzer, Abbott CELL-DYN 4000 (CD 4000), capable of providing 26 parameters, including fully automated reticulocyte, nucleated RBC, blast, band, and immature granulocyte, and variant lymphocyte counts, was evaluated by using the National Committee for Clinical Laboratory Standards H20-A protocol and compared with the Bayer-Technicon H-2 analyzer, which is used routinely in our laboratory. A lipid interference experiment and a sample aging study also were performed. Linearity, carryover, and precision were within the limits established by the manufacturer, and satisfactory agreement was found with the H-2 analyzer. The evaluation of leukocyte differential counts indicated an excellent correlation with the manual reference method for neutrophils and lymphocytes, a good correlation for monocytes and eosinophils, and a poor correlation for basophils in samples with low counts; for basophil counts of 2% or higher, we found an improvement of the correlation coefficient. In the lipid interference experiment, only hemoglobin determination was influenced significantly on the CD 4000, but by using a new Abbott hemoglobin reagent, the interference was eliminated. The CBC and differential counts were stable and reportable up to at least 24 hours. Intrasample viability information on leukocytes provided a quality check on each individual specimen.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>10761450</pmid><doi>10.1309/L7LC-6KKJ-12G2-196W</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0002-9173 |
ispartof | American journal of clinical pathology, 2000-04, Vol.113 (4), p.497-505 |
issn | 0002-9173 1943-7722 |
language | eng |
recordid | cdi_proquest_miscellaneous_71039482 |
source | Oxford Journals Online |
subjects | Autoanalysis Biological and medical sciences Blood Cell Count - instrumentation Evaluation Studies as Topic Hematology Hematology - instrumentation Humans Investigative techniques, diagnostic techniques (general aspects) Lipids - blood Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reproducibility of Results Specimen Handling |
title | Evaluation of the Abbott CELL-DYN 4000 hematology analyzer |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T11%3A46%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20Abbott%20CELL-DYN%204000%20hematology%20analyzer&rft.jtitle=American%20journal%20of%20clinical%20pathology&rft.au=GRIMALDI,%20E&rft.date=2000-04-01&rft.volume=113&rft.issue=4&rft.spage=497&rft.epage=505&rft.pages=497-505&rft.issn=0002-9173&rft.eissn=1943-7722&rft.coden=AJCPAI&rft_id=info:doi/10.1309/L7LC-6KKJ-12G2-196W&rft_dat=%3Cproquest_cross%3E71039482%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c307t-dc80e7704093cac1e2410f9a2b72785c627e8131cae0da477b70a20d2c9b5fde3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=71039482&rft_id=info:pmid/10761450&rfr_iscdi=true |