Three new triterpenoids from Peganum nigellastrum

Three new triterpenoids, 3alpha,27-dihydroxylup-20(29)-en-28-oic acid methyl ester, 3alpha-acetoxy-27-hydroxylup-20(29)-en-28-oic acid methyl ester, and 3alpha-acetoxyolean-12-ene-27,28-dioic acid 28-methyl ester, were isolated from the roots of Peganum nigellastrum along with four known lupene-type...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2000-03, Vol.63 (3), p.390-392
Main Authors: Ma, Z.Z, Hano, Y, Nomura, T, Chen, Y.J
Format: Article
Language:English
Subjects:
Biological and medical sciences
chemical constituents of plants
chemical structure
DNA Topoisomerases, Type II - drug effects
General pharmacology
Humans
Medical sciences
medicinal plants
Molecular Structure
Peganum
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
roots
spectral analysis
Spectrum Analysis
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
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Summary:Three new triterpenoids, 3alpha,27-dihydroxylup-20(29)-en-28-oic acid methyl ester, 3alpha-acetoxy-27-hydroxylup-20(29)-en-28-oic acid methyl ester, and 3alpha-acetoxyolean-12-ene-27,28-dioic acid 28-methyl ester, were isolated from the roots of Peganum nigellastrum along with four known lupene-type triterpenoids. The structures of the new triterpenoids were determined by NMR spectroscopic means. The new triterpene, 3alpha, 27-dihydroxylup-20(29)-en-28-oic acid methyl ester is a DNA topoisomerase II inhibitor (IC(50) = 8.9 microM/mL).
ISSN:0163-3864
1520-6025
DOI:10.1021/np990227b