Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice

This investigation reports the possible role of the endocannabinoid anandamide on modulating the behavioral and neurochemical consequences of semi-starvation. We studied the effect of very low dose anandamide (0.001 mg/kg) administration on food intake, cognitive function and catecholaminergic and s...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2000-03, Vol.392 (3), p.147-156
Main Authors: Hao, Shuzhen, Avraham, Yosefa, Mechoulam, Raphael, Berry, Elliot M
Format: Article
Language:English
Subjects:
Anandamide
Animals
Arachidonic Acids - pharmacology
Behavioral psychophysiology
Biological and medical sciences
Cannabinoid Receptor Modulators
Catecholamine, 5-hydroxytryptamine, serotonin (5-HT)
Catecholamines - metabolism
Cognition - drug effects
Cognition - physiology
Cognitive function
Corticosterone
Corticosterone - metabolism
Diet
Diet restriction
Dose-Response Relationship, Drug
Eating - drug effects
Endocannabinoids
Feeding. Feeding behavior
Female
Food intake
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Hypothalamus
Hypothalamus - drug effects
Hypothalamus - metabolism
Maze Learning - drug effects
Mice
Mice, Inbred BALB C
Neurotransmission and behavior
Neurotransmitter Agents - metabolism
Polyunsaturated Alkamides
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychomotor Performance - drug effects
Serotonin - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This investigation reports the possible role of the endocannabinoid anandamide on modulating the behavioral and neurochemical consequences of semi-starvation. We studied the effect of very low dose anandamide (0.001 mg/kg) administration on food intake, cognitive function and catecholaminergic and serotonergic pathways in two murine brain areas concerned with appetite (hypothalamus) and learning (hippocampus), and the peripheral corticosterone response to the stress of 40% diet restriction. Anandamide-treated mice consumed 44% more food ( P
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(00)00059-5