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Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice
This investigation reports the possible role of the endocannabinoid anandamide on modulating the behavioral and neurochemical consequences of semi-starvation. We studied the effect of very low dose anandamide (0.001 mg/kg) administration on food intake, cognitive function and catecholaminergic and s...
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| Published in: | European journal of pharmacology 2000-03, Vol.392 (3), p.147-156 |
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| container_title | European journal of pharmacology |
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| creator | Hao, Shuzhen Avraham, Yosefa Mechoulam, Raphael Berry, Elliot M |
| description | This investigation reports the possible role of the endocannabinoid anandamide on modulating the behavioral and neurochemical consequences of semi-starvation. We studied the effect of very low dose anandamide (0.001 mg/kg) administration on food intake, cognitive function and catecholaminergic and serotonergic pathways in two murine brain areas concerned with appetite (hypothalamus) and learning (hippocampus), and the peripheral corticosterone response to the stress of 40% diet restriction. Anandamide-treated mice consumed 44% more food (
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| doi_str_mv | 10.1016/S0014-2999(00)00059-5 |
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P<0.05) during 1 week of 2.5-h feeding each day. In the hypothalamus, there were significantly increased concentrations of norepinephrine (
P<0.01), dopamine (
P<0.05) and 5-hydroxytryptamine (5-HT) (
P<0.001). In the hippocampus, anandamide increased significantly norepinephrine and dopamine, but decreased 5-HT (all at
P<0.001). Diet restriction was accompanied in both areas by a significant decrease in all neurotransmitter concentrations that were partially restored by anandamide for dopamine and 5-HT, but not for norepinephrine. In animals on diet restriction, anandamide significantly improved impaired maze performance. Norepinephrine turnover and plasma corticosterone levels were also raised significantly by anandamide. The fact that low dose anandamide improved food intake, cognitive function and reversed some of the neurotransmitter changes caused by diet restriction, might have implications for the treatment of cachexia associated with acquired immunodeficiency syndrome (AIDS) and cancer, for mood changes sometimes associated with dieting, and in the extreme case, of patients with anorexia.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/S0014-2999(00)00059-5</identifier><identifier>PMID: 10762668</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Anandamide ; Animals ; Arachidonic Acids - pharmacology ; Behavioral psychophysiology ; Biological and medical sciences ; Cannabinoid Receptor Modulators ; Catecholamine, 5-hydroxytryptamine, serotonin (5-HT) ; Catecholamines - metabolism ; Cognition - drug effects ; Cognition - physiology ; Cognitive function ; Corticosterone ; Corticosterone - metabolism ; Diet ; Diet restriction ; Dose-Response Relationship, Drug ; Eating - drug effects ; Endocannabinoids ; Feeding. Feeding behavior ; Female ; Food intake ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hypothalamus ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Maze Learning - drug effects ; Mice ; Mice, Inbred BALB C ; Neurotransmission and behavior ; Neurotransmitter Agents - metabolism ; Polyunsaturated Alkamides ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance - drug effects ; Serotonin - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>European journal of pharmacology, 2000-03, Vol.392 (3), p.147-156</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-dfc88c74101e53180583771b1d48c951f879190006cff0e94f65c09b8f4980b13</citedby><cites>FETCH-LOGICAL-c456t-dfc88c74101e53180583771b1d48c951f879190006cff0e94f65c09b8f4980b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1336413$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10762668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hao, Shuzhen</creatorcontrib><creatorcontrib>Avraham, Yosefa</creatorcontrib><creatorcontrib>Mechoulam, Raphael</creatorcontrib><creatorcontrib>Berry, Elliot M</creatorcontrib><title>Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>This investigation reports the possible role of the endocannabinoid anandamide on modulating the behavioral and neurochemical consequences of semi-starvation. We studied the effect of very low dose anandamide (0.001 mg/kg) administration on food intake, cognitive function and catecholaminergic and serotonergic pathways in two murine brain areas concerned with appetite (hypothalamus) and learning (hippocampus), and the peripheral corticosterone response to the stress of 40% diet restriction. Anandamide-treated mice consumed 44% more food (
P<0.05) during 1 week of 2.5-h feeding each day. In the hypothalamus, there were significantly increased concentrations of norepinephrine (
P<0.01), dopamine (
P<0.05) and 5-hydroxytryptamine (5-HT) (
P<0.001). In the hippocampus, anandamide increased significantly norepinephrine and dopamine, but decreased 5-HT (all at
P<0.001). Diet restriction was accompanied in both areas by a significant decrease in all neurotransmitter concentrations that were partially restored by anandamide for dopamine and 5-HT, but not for norepinephrine. In animals on diet restriction, anandamide significantly improved impaired maze performance. Norepinephrine turnover and plasma corticosterone levels were also raised significantly by anandamide. The fact that low dose anandamide improved food intake, cognitive function and reversed some of the neurotransmitter changes caused by diet restriction, might have implications for the treatment of cachexia associated with acquired immunodeficiency syndrome (AIDS) and cancer, for mood changes sometimes associated with dieting, and in the extreme case, of patients with anorexia.</description><subject>Anandamide</subject><subject>Animals</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cannabinoid Receptor Modulators</subject><subject>Catecholamine, 5-hydroxytryptamine, serotonin (5-HT)</subject><subject>Catecholamines - metabolism</subject><subject>Cognition - drug effects</subject><subject>Cognition - physiology</subject><subject>Cognitive function</subject><subject>Corticosterone</subject><subject>Corticosterone - metabolism</subject><subject>Diet</subject><subject>Diet restriction</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eating - drug effects</subject><subject>Endocannabinoids</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hypothalamus</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Maze Learning - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neurotransmission and behavior</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Polyunsaturated Alkamides</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance - drug effects</subject><subject>Serotonin - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkU2PFCEQhonRuOPoT9BwMEaTbS2mgW5Oxmz8SibxoJ4JA4VBu2EFeoyn_euyMxN3b3vhI3mqqPeBkKcMXjNg8s1XAMa7jVLqJcArABCqE_fIio2D6mBgm_tk9R85I49K-XmANuIhOWMwyI2U44pcbdMf6lJBaqKJzszBtaP3aGuhPiVHQ6zmF55Tm37EUMMeqV-irSHFcxpxyalmE8scasXcmrgG5hpsKu2eItIJ9ziV1oa6gLXLWGoOtqKjc7D4mDzwZir45LSvyfcP779dfOq2Xz5-vni37SwXsnbO23G0A2_RUfRsBDH2w8B2zPHRKsF8S81UCyit94CKeyksqN3ouRphx_o1eXHse5nT76XNoOdQLE6TiZiWogcGnA2SN1AcQZtTKRm9vsxhNvmvZqCvzeuDeX2tVQPog1QtWt2z0wPLbkZ3q-qougHPT4Ap1ky-WbOh3HB9L3lb1uTtEWvScB8w62IDRosu5PYp2qVwxyT_AP8FoT4</recordid><startdate>20000331</startdate><enddate>20000331</enddate><creator>Hao, Shuzhen</creator><creator>Avraham, Yosefa</creator><creator>Mechoulam, Raphael</creator><creator>Berry, Elliot M</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000331</creationdate><title>Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice</title><author>Hao, Shuzhen ; Avraham, Yosefa ; Mechoulam, Raphael ; Berry, Elliot M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-dfc88c74101e53180583771b1d48c951f879190006cff0e94f65c09b8f4980b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anandamide</topic><topic>Animals</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cannabinoid Receptor Modulators</topic><topic>Catecholamine, 5-hydroxytryptamine, serotonin (5-HT)</topic><topic>Catecholamines - metabolism</topic><topic>Cognition - drug effects</topic><topic>Cognition - physiology</topic><topic>Cognitive function</topic><topic>Corticosterone</topic><topic>Corticosterone - metabolism</topic><topic>Diet</topic><topic>Diet restriction</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eating - drug effects</topic><topic>Endocannabinoids</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hypothalamus</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Maze Learning - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neurotransmission and behavior</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Polyunsaturated Alkamides</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychomotor Performance - drug effects</topic><topic>Serotonin - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao, Shuzhen</creatorcontrib><creatorcontrib>Avraham, Yosefa</creatorcontrib><creatorcontrib>Mechoulam, Raphael</creatorcontrib><creatorcontrib>Berry, Elliot M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Shuzhen</au><au>Avraham, Yosefa</au><au>Mechoulam, Raphael</au><au>Berry, Elliot M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2000-03-31</date><risdate>2000</risdate><volume>392</volume><issue>3</issue><spage>147</spage><epage>156</epage><pages>147-156</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>This investigation reports the possible role of the endocannabinoid anandamide on modulating the behavioral and neurochemical consequences of semi-starvation. We studied the effect of very low dose anandamide (0.001 mg/kg) administration on food intake, cognitive function and catecholaminergic and serotonergic pathways in two murine brain areas concerned with appetite (hypothalamus) and learning (hippocampus), and the peripheral corticosterone response to the stress of 40% diet restriction. Anandamide-treated mice consumed 44% more food (
P<0.05) during 1 week of 2.5-h feeding each day. In the hypothalamus, there were significantly increased concentrations of norepinephrine (
P<0.01), dopamine (
P<0.05) and 5-hydroxytryptamine (5-HT) (
P<0.001). In the hippocampus, anandamide increased significantly norepinephrine and dopamine, but decreased 5-HT (all at
P<0.001). Diet restriction was accompanied in both areas by a significant decrease in all neurotransmitter concentrations that were partially restored by anandamide for dopamine and 5-HT, but not for norepinephrine. In animals on diet restriction, anandamide significantly improved impaired maze performance. Norepinephrine turnover and plasma corticosterone levels were also raised significantly by anandamide. The fact that low dose anandamide improved food intake, cognitive function and reversed some of the neurotransmitter changes caused by diet restriction, might have implications for the treatment of cachexia associated with acquired immunodeficiency syndrome (AIDS) and cancer, for mood changes sometimes associated with dieting, and in the extreme case, of patients with anorexia.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10762668</pmid><doi>10.1016/S0014-2999(00)00059-5</doi><tpages>10</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 2000-03, Vol.392 (3), p.147-156 |
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| subjects | Anandamide Animals Arachidonic Acids - pharmacology Behavioral psychophysiology Biological and medical sciences Cannabinoid Receptor Modulators Catecholamine, 5-hydroxytryptamine, serotonin (5-HT) Catecholamines - metabolism Cognition - drug effects Cognition - physiology Cognitive function Corticosterone Corticosterone - metabolism Diet Diet restriction Dose-Response Relationship, Drug Eating - drug effects Endocannabinoids Feeding. Feeding behavior Female Food intake Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Maze Learning - drug effects Mice Mice, Inbred BALB C Neurotransmission and behavior Neurotransmitter Agents - metabolism Polyunsaturated Alkamides Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - drug effects Serotonin - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice |
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