Inhibitor of tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa

Certain flavonoids were reported to show an immunoregulatory activity against lymphocyte proliferation and cytokine production. In the course of a search for tumor necrosis factor (TNF)-α inhibitory compounds from natural plants, we also isolated a prenylfavanone type of flavonoid, amoradicin, from...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-05, Vol.70 (2), p.127-133
Main Authors: Cho, Jae Youl, Kim, Pyoung Su, Park, Jisoo, Yoo, Eun Sook, Baik, Kyong Up, Kim, Young-Kyoon, Park, Myung Hwan
Format: Article
Language:English
Subjects:
Amoradicin
Amorpha fruticosa
Animals
Biological and medical sciences
Cell Line
Flavonoids - pharmacology
General pharmacology
Genistein
Genistein - pharmacology
Korea
Leguminosae
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Macrophages - metabolism
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Silybin
Silymarin - pharmacology
Structure-Activity Relationship
TNF-α production
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor Necrosis Factor-alpha - biosynthesis
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Summary:Certain flavonoids were reported to show an immunoregulatory activity against lymphocyte proliferation and cytokine production. In the course of a search for tumor necrosis factor (TNF)-α inhibitory compounds from natural plants, we also isolated a prenylfavanone type of flavonoid, amoradicin, from the extract of Amorpha fruticosa by activity-guided fractionation. This compound significantly inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells with an IC 50 value of 28.5 μM. The activity was comparable or higher than those of standard flavonoid compounds, genistein and silybin with IC 50 of 24.9 and 140.3 μM, respectively.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(99)00154-3