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Inhibitor of tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa
Certain flavonoids were reported to show an immunoregulatory activity against lymphocyte proliferation and cytokine production. In the course of a search for tumor necrosis factor (TNF)-α inhibitory compounds from natural plants, we also isolated a prenylfavanone type of flavonoid, amoradicin, from...
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| Published in: | Journal of ethnopharmacology 2000-05, Vol.70 (2), p.127-133 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c390t-58625c8ce98dfe96e8bd4d5ecf16b78a9b500b5bb5d4aa27dd485ba7a127f14a3 |
| container_end_page | 133 |
| container_issue | 2 |
| container_start_page | 127 |
| container_title | Journal of ethnopharmacology |
| container_volume | 70 |
| creator | Cho, Jae Youl Kim, Pyoung Su Park, Jisoo Yoo, Eun Sook Baik, Kyong Up Kim, Young-Kyoon Park, Myung Hwan |
| description | Certain flavonoids were reported to show an immunoregulatory activity against lymphocyte proliferation and cytokine production. In the course of a search for tumor necrosis factor (TNF)-α inhibitory compounds from natural plants, we also isolated a prenylfavanone type of flavonoid, amoradicin, from the extract of
Amorpha fruticosa by activity-guided fractionation. This compound significantly inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells with an IC
50 value of 28.5 μM. The activity was comparable or higher than those of standard flavonoid compounds, genistein and silybin with IC
50 of 24.9 and 140.3 μM, respectively. |
| doi_str_mv | 10.1016/S0378-8741(99)00154-3 |
| format | article |
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Amorpha fruticosa by activity-guided fractionation. This compound significantly inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells with an IC
50 value of 28.5 μM. The activity was comparable or higher than those of standard flavonoid compounds, genistein and silybin with IC
50 of 24.9 and 140.3 μM, respectively.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(99)00154-3</identifier><identifier>PMID: 10771202</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Amoradicin ; Amorpha fruticosa ; Animals ; Biological and medical sciences ; Cell Line ; Flavonoids - pharmacology ; General pharmacology ; Genistein ; Genistein - pharmacology ; Korea ; Leguminosae ; Lipopolysaccharides - pharmacology ; Macrophages - drug effects ; Macrophages - metabolism ; Medical sciences ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; Silybin ; Silymarin - pharmacology ; Structure-Activity Relationship ; TNF-α production ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor Necrosis Factor-alpha - biosynthesis</subject><ispartof>Journal of ethnopharmacology, 2000-05, Vol.70 (2), p.127-133</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-58625c8ce98dfe96e8bd4d5ecf16b78a9b500b5bb5d4aa27dd485ba7a127f14a3</citedby><cites>FETCH-LOGICAL-c390t-58625c8ce98dfe96e8bd4d5ecf16b78a9b500b5bb5d4aa27dd485ba7a127f14a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1349471$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10771202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Jae Youl</creatorcontrib><creatorcontrib>Kim, Pyoung Su</creatorcontrib><creatorcontrib>Park, Jisoo</creatorcontrib><creatorcontrib>Yoo, Eun Sook</creatorcontrib><creatorcontrib>Baik, Kyong Up</creatorcontrib><creatorcontrib>Kim, Young-Kyoon</creatorcontrib><creatorcontrib>Park, Myung Hwan</creatorcontrib><title>Inhibitor of tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Certain flavonoids were reported to show an immunoregulatory activity against lymphocyte proliferation and cytokine production. In the course of a search for tumor necrosis factor (TNF)-α inhibitory compounds from natural plants, we also isolated a prenylfavanone type of flavonoid, amoradicin, from the extract of
Amorpha fruticosa by activity-guided fractionation. This compound significantly inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells with an IC
50 value of 28.5 μM. The activity was comparable or higher than those of standard flavonoid compounds, genistein and silybin with IC
50 of 24.9 and 140.3 μM, respectively.</description><subject>Amoradicin</subject><subject>Amorpha fruticosa</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Flavonoids - pharmacology</subject><subject>General pharmacology</subject><subject>Genistein</subject><subject>Genistein - pharmacology</subject><subject>Korea</subject><subject>Leguminosae</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>Silybin</subject><subject>Silymarin - pharmacology</subject><subject>Structure-Activity Relationship</subject><subject>TNF-α production</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkMtu1DAUhi1ERYfCI4C8QBUsUuzEju0VGlVcKlVC4iKWli8nGqMkDrZD1cfiRfpMeDojYMfKtvyd_5zzIfSMkgtKaP_6M-mEbKRg9KVSrwihnDXdA7ShUrSN4KJ7iDZ_kFP0OOfvhBBBGXmETikRgrak3aCbq3kXbCgx4Tjgsk71MoNLMYeMB-PqR3P3Cy8p-tWVEGccZjyGJS5xvM3GuZ1JwUOTS5jW0RTw-NP2W9uzC4EdjGMNSXHC25q77Ex9rCW4mM0TdDKYMcPT43mGvr57--XyQ3P98f3V5fa6cZ0ipeGyb7mTDpT0A6gepPXMc3AD7a2QRllOiOXWcs-MaYX3THJrhKGtGCgz3Rk6P-TWDX6skIueQt4PZmaIa9aCEtZRyivID-B-95xg0EsKk0m3mhK9N67vjeu9Tq2Uvjeuu1r3_NhgtRP4f6oOiivw4giY7Mw4JDO7kP9yHVNM0Iq9OWBQbfwMkHR2AWYHPiRwRfsY_jPJb0GFoCA</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>Cho, Jae Youl</creator><creator>Kim, Pyoung Su</creator><creator>Park, Jisoo</creator><creator>Yoo, Eun Sook</creator><creator>Baik, Kyong Up</creator><creator>Kim, Young-Kyoon</creator><creator>Park, Myung Hwan</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000501</creationdate><title>Inhibitor of tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa</title><author>Cho, Jae Youl ; Kim, Pyoung Su ; Park, Jisoo ; Yoo, Eun Sook ; Baik, Kyong Up ; Kim, Young-Kyoon ; Park, Myung Hwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-58625c8ce98dfe96e8bd4d5ecf16b78a9b500b5bb5d4aa27dd485ba7a127f14a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Amoradicin</topic><topic>Amorpha fruticosa</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Flavonoids - pharmacology</topic><topic>General pharmacology</topic><topic>Genistein</topic><topic>Genistein - pharmacology</topic><topic>Korea</topic><topic>Leguminosae</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>Silybin</topic><topic>Silymarin - pharmacology</topic><topic>Structure-Activity Relationship</topic><topic>TNF-α production</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Jae Youl</creatorcontrib><creatorcontrib>Kim, Pyoung Su</creatorcontrib><creatorcontrib>Park, Jisoo</creatorcontrib><creatorcontrib>Yoo, Eun Sook</creatorcontrib><creatorcontrib>Baik, Kyong Up</creatorcontrib><creatorcontrib>Kim, Young-Kyoon</creatorcontrib><creatorcontrib>Park, Myung Hwan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Jae Youl</au><au>Kim, Pyoung Su</au><au>Park, Jisoo</au><au>Yoo, Eun Sook</au><au>Baik, Kyong Up</au><au>Kim, Young-Kyoon</au><au>Park, Myung Hwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitor of tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>70</volume><issue>2</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Certain flavonoids were reported to show an immunoregulatory activity against lymphocyte proliferation and cytokine production. In the course of a search for tumor necrosis factor (TNF)-α inhibitory compounds from natural plants, we also isolated a prenylfavanone type of flavonoid, amoradicin, from the extract of
Amorpha fruticosa by activity-guided fractionation. This compound significantly inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells with an IC
50 value of 28.5 μM. The activity was comparable or higher than those of standard flavonoid compounds, genistein and silybin with IC
50 of 24.9 and 140.3 μM, respectively.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10771202</pmid><doi>10.1016/S0378-8741(99)00154-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2000-05, Vol.70 (2), p.127-133 |
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| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Amoradicin Amorpha fruticosa Animals Biological and medical sciences Cell Line Flavonoids - pharmacology General pharmacology Genistein Genistein - pharmacology Korea Leguminosae Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Silybin Silymarin - pharmacology Structure-Activity Relationship TNF-α production Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis |
| title | Inhibitor of tumor necrosis factor-α production in lipopolysaccharide-stimulated RAW264.7 cells from Amorpha fruticosa |
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