Biotransformation of Selamectin with Streptomyces lydicus SX-1298 Using a Novel Static Agar Fermentation System with Reemay® Mesh

A novel approach to biotransformation is described using a solid medium matrix and Reemay® mesh that gives efficient biotransformation of compounds with minimal matrices in the ensuing gum solids. Using this approach with a newly isolated biotransforming organism, Streptomyces lydicus SX1298, a seri...

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Bibliographic Details
Published in:Journal of antibiotics 2001/05/25, Vol.54(5), pp.448-454
Main Authors: PACEY, MICHAEL S., BARNES, MARION M., MONDAY, ROBERT A., RITZAU, MICHAEL, WELLINGTON, ELIZABETH M. H.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiparasitic Agents - chemistry
Antiparasitic Agents - metabolism
Antiparasitic Agents - pharmacokinetics
Biological and medical sciences
Biotransformation
Chromatography, Liquid
Fermentation
Ivermectin - analogs & derivatives
Ivermectin - chemistry
Ivermectin - metabolism
Ivermectin - pharmacokinetics
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Pharmacology. Drug treatments
Streptomyces - metabolism
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Summary:A novel approach to biotransformation is described using a solid medium matrix and Reemay® mesh that gives efficient biotransformation of compounds with minimal matrices in the ensuing gum solids. Using this approach with a newly isolated biotransforming organism, Streptomyces lydicus SX1298, a series of hydroxylations and an O-demethylation is described for selamectin the first endectocide for cats and dogs.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.54.448