Biotransformation of Selamectin with Streptomyces lydicus SX-1298 Using a Novel Static Agar Fermentation System with Reemay® Mesh

A novel approach to biotransformation is described using a solid medium matrix and Reemay® mesh that gives efficient biotransformation of compounds with minimal matrices in the ensuing gum solids. Using this approach with a newly isolated biotransforming organism, Streptomyces lydicus SX1298, a seri...

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Published in:Journal of antibiotics 2001/05/25, Vol.54(5), pp.448-454
Main Authors: PACEY, MICHAEL S., BARNES, MARION M., MONDAY, ROBERT A., RITZAU, MICHAEL, WELLINGTON, ELIZABETH M. H.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiparasitic Agents - chemistry
Antiparasitic Agents - metabolism
Antiparasitic Agents - pharmacokinetics
Biological and medical sciences
Biotransformation
Chromatography, Liquid
Fermentation
Ivermectin - analogs & derivatives
Ivermectin - chemistry
Ivermectin - metabolism
Ivermectin - pharmacokinetics
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Pharmacology. Drug treatments
Streptomyces - metabolism
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cited_by cdi_FETCH-LOGICAL-c506t-9eaeb587dce599b0d9fc521314eeb31fc7eb3a0721b7e587e9fb72b70002c2a53
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container_end_page 454
container_issue 5
container_start_page 448
container_title Journal of antibiotics
container_volume 54
creator PACEY, MICHAEL S.
BARNES, MARION M.
MONDAY, ROBERT A.
RITZAU, MICHAEL
WELLINGTON, ELIZABETH M. H.
description A novel approach to biotransformation is described using a solid medium matrix and Reemay® mesh that gives efficient biotransformation of compounds with minimal matrices in the ensuing gum solids. Using this approach with a newly isolated biotransforming organism, Streptomyces lydicus SX1298, a series of hydroxylations and an O-demethylation is described for selamectin the first endectocide for cats and dogs.
doi_str_mv 10.7164/antibiotics.54.448
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ispartof The Journal of Antibiotics, 2001/05/25, Vol.54(5), pp.448-454
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subjects Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiparasitic Agents - chemistry
Antiparasitic Agents - metabolism
Antiparasitic Agents - pharmacokinetics
Biological and medical sciences
Biotransformation
Chromatography, Liquid
Fermentation
Ivermectin - analogs & derivatives
Ivermectin - chemistry
Ivermectin - metabolism
Ivermectin - pharmacokinetics
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Pharmacology. Drug treatments
Streptomyces - metabolism
title Biotransformation of Selamectin with Streptomyces lydicus SX-1298 Using a Novel Static Agar Fermentation System with Reemay® Mesh
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