Epithelioid sarcoma arising on the nose of a child: a case report and review of the literature

A 4‐year‐old boy presented with a 6‐month history of a red papule on the nasal septum. Physical examination was otherwise unremarkable. A biopsy specimen showed an epithelioid sarcoma characterized by nodular collections of epithelioid tumor cells with central, tumor cell necrosis. By immunohistoche...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2000-04, Vol.27 (4), p.186-190
Main Authors: Billings, Steven D., Hood, Antoinette F.
Format: Article
Language:English
Subjects:
Antigens, CD34 - analysis
Biological and medical sciences
Biomarkers, Tumor - analysis
Child, Preschool
Dermatology
Diagnosis, Differential
Humans
Immunohistochemistry
Keratins - analysis
Male
Medical sciences
Mucin-1 - analysis
Neoplasm Proteins - analysis
Nose
Otorhinolaryngology. Stomatology
Sarcoma - chemistry
Sarcoma - pathology
Skin Neoplasms - chemistry
Skin Neoplasms - pathology
Tumors
Tumors of the skin and soft tissue. Premalignant lesions
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Vimentin - analysis
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Description
Summary:A 4‐year‐old boy presented with a 6‐month history of a red papule on the nasal septum. Physical examination was otherwise unremarkable. A biopsy specimen showed an epithelioid sarcoma characterized by nodular collections of epithelioid tumor cells with central, tumor cell necrosis. By immunohistochemistry the tumor cells were positive for cytokeratin, epithelial membrane antigen, vimentin, and CD34, but negative for S‐100, CD31, factor VIII‐related antigen, CD68, actin, desmin and myoglobin. Epithelioid sarcoma is an uncommon tumor of uncertain histogenesis that typically arises in the extremities of young adults. Both the age of our patient and the location of his tumor are unusual, emphasizing the spectrum of presentations that may occur with epithelioid sarcoma. Epithelioid sarcoma should be considered in the differential diagnosis of granulomatous diseases and epithelioid tumors of children, even in unusual locations.
ISSN:0303-6987
1600-0560
DOI:10.1034/j.1600-0560.2000.027004186.x