The expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relatives

Fragile sites are non-staining gaps and breaks in specific points of chromosomes. These sites also include acentric fragments, triradial figures and several rearrangements. Although this issue has been controversial recently, they may be related to structural chromosomal rearrangement in some neopla...

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Bibliographic Details
Published in:Cancer letters 2000-05, Vol.152 (2), p.201-209
Main Authors: Tunca, Berrin, Egeli, Ünal, Zorluoğlu, Abdullah, Yılmazlar, Tuncay, Yerci, Ömer, Kızıl, Ayhan
Format: Article
Language:English
Subjects:
Adult
Aged
Aphidicolin - pharmacology
Biological and medical sciences
Bromodeoxyuridine - pharmacology
Caffeine - pharmacology
Case-Control Studies
Cells, Cultured
Chromosome Breakage
Chromosome Fragile Sites
Chromosome Fragility
DNA Damage
Family Health
Female
Fragile sites
Gastroenterology. Liver. Pancreas. Abdomen
Genetic Predisposition to Disease
Genetic susceptibility
Humans
Lymphocytes - ultrastructure
Male
Medical sciences
Metaphase
Middle Aged
Rectal Neoplasms - genetics
Rectum cancer
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Fragile sites are non-staining gaps and breaks in specific points of chromosomes. These sites also include acentric fragments, triradial figures and several rearrangements. Although this issue has been controversial recently, they may be related to structural chromosomal rearrangement in some neoplasms. In this study, the expression of fragile sites induced by aphidicolin (Apc), 5-bromodeoxyuridine (BrdU) and caffeine was investigated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 36 patients with rectum cancer, 30 first-degree relatives and 30 normal healthy controls. The results of the structural chromosome aberrations determined in patients and their first-degree relatives were significantly higher than those in control subjects ( P
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(00)00334-7