Some particularities of sodium nitroprusside stimulatory effects on food intake

It was previously shown that sodium nitroprusside (NP) stimulates food (FI) and water (WI) intakes when injected intraperitoneally (i.p.) in male rats deprived for 1-h of both food and water during day time. The present work shows that: 1) intramuscular NP increased only water intake; 2) when NP was...

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Bibliographic Details
Published in:Life sciences (1973) 2001-06, Vol.69 (6), p.659-668
Main Authors: Racotta, Radu, Soto-Mora, Luz Marı́a, Piñón, Manuel, Quevedo, Lucı́a
Format: Article
Language:English
Subjects:
Animals
Eating - drug effects
Food Deprivation
Food intake
Injections, Intramuscular
Male
Nitroprusside
Nitroprusside - administration & dosage
Nitroprusside - pharmacology
Rats
Rats, Wistar
Route of administration
Time Factors
Water Deprivation
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Summary:It was previously shown that sodium nitroprusside (NP) stimulates food (FI) and water (WI) intakes when injected intraperitoneally (i.p.) in male rats deprived for 1-h of both food and water during day time. The present work shows that: 1) intramuscular NP increased only water intake; 2) when NP was i.p. injected simultaneously without 1-h deprivation it slightly reduced both intakes in the first 30 min but stimulated significantly FI between 30 and 60 min, and 3) it increased significantly FI even in absence of available water, while WI in absence of food was practically not affected. In conclusion NP effect on FI does originate mainly in the splanchnic area, it requires a latency of about 30 min, and stimulation of FI by NP triggers an increase in WI and not the other way around.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(01)01157-2